Modafinil and Kratom

Modafinil and Kratom: Are they safe to mix?

Modafinil and Kratom are two drugs that have been rising in popularity, but some people should really be careful before using them. Learn the side effects of these nootropics & what to watch out for when you’re trying to stay healthy.

Kratom and adrafinil are two substances that have been popular in recent times. These drugs are often used to help people stay awake, or to treat depression. Some people use these drugs recreationally, while others turn to them as a treatment for chronic pain. Read more in detail here: kratom adrafinil.

You’ve come to the correct site if you’re searching for the most complete guide on mixing Modafinil and Kratom on the Internet.

Both medications have a bad reputation among doctors, but for different reasons.

Modafinil is a “super-performance” medication that boosts productivity dramatically.

It may be taken on its alone for hours of much-needed attention in today’s world of constant distractions, or it can be combined with other nootropics to form a powerful combo.

Kratom, on the other hand, has a unique origin narrative. According to the FDA and other regulatory agencies, Kratom cannot be used to treat any medical ailment safely or efficiently.

However, if you question others who have used it, they will tell you a different story. Kratom is effective for reducing anxiety, treating opioid withdrawal symptoms, and managing moderate to severe pain.

Kratom and Modafinil seem to be a strange pairing: one calms you, while the other energizes you.

What exactly is Modafinil?

Allow me to refresh your memory on Modafinil in case you’ve never heard of it before…

Modafinil is a prescription medicine that promotes wakefulness and was licensed by the FDA in December 1998 for the treatment of narcolepsy. As it increases wakefulness and fends off sleep without acting as a stimulant, Modafinil is classed as a ‘eugeroic’.

What is a Eugeroic?

If you’ve never come across the term ‘eugeroic’ before, you’re not alone. While this word is rarely used in day-to-day life, it is a key category of nootropics of which Modafinil is the prototypical example.

A eugeroic is a substance which promotes wakefulness, prevents sleep and increases alertness. These are typically used to treat sleep disorders such as narcolepsy or excessive daytime sleepiness. Importantly, eugeroics are not psychostimulants like methylphenidate or Adderall; they do not work by exciting the CNS, they do not produce any kind of stimulant ‘high’, and as such, they carry a far lower risk of addiction and side effects.

Other Benefits of Modafinil

Besides narcolepsy, Modafinil has been prescribed for shift work sleep disorder and obstructive sleep apnea. Basically, any situation in which the patient’s excessive drowsiness is a significant problem[1].

People have learned that Modafinil can accomplish so much more since 1998.

Several healthy people, particularly those in high-stress occupations, discovered that Modafinil may significantly improve the intensity and length of their focus.

Modafinil is now well-known for its off-label uses, which include assisting individuals in getting “things” done better and quicker while outworking their opponents.

And how does this nootropic function in your brain? Researchers who have been examining this medicine for many decades are unsure.

Modafinil enhances dopamine (the “feel good” neurotransmitter) in the brain by delaying its breakdown, according to research.

This explains why Modafinil users experience such a strong rush of motivation after taking it.

With this in mind, why would anybody consider combining Modafinil and Kratom? To answer that question, we first need to find out what Kratom is and what it does to the brain.

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What exactly is Kratom?

We can better comprehend why mixing Kratom with Modafinil doesn’t seem so far-fetched if we learn more about its origins and what it does to our mental function.

Kratom, also known as Mitragyna speciosa, is a tropical tree native to Indonesia, Thailand, and other Southeast Asian nations. It goes by numerous names in those nations, including “Ketum” and “Thom.”

The leaf extracts have been used in traditional medicine for hundreds of years to treat digestive issues, exhaustion, discomfort, and a variety of other diseases.

However, its use has changed dramatically since then. Today, you’ll see that many individuals are utilizing it as a recreational substance to experience a different kind of high.

At the same time, many medical patients recommend Kratom as a helpful strategy to alleviate chronic pain and narcotic withdrawal symptoms.

So, how does Kratom function?

Kratom’s effects are attributed to two main active ingredients[2]:

  • Mitragynine
  • 7-hydroxymitragynine

Many people think Kratom works as an opiate because both of these chemicals connect to the primary opioid receptors located in our brain and spinal cord.

Kratom’s pain-relieving properties are delivered to the user in this way.

It’s worth mentioning that powerful opioids like morphine, fentanyl, and others bind to the same receptors. However, they bind to these receptors 10-100 times more strongly than mitragynine or 7-hydroxymitragynine, making it misleading to label Kratom as a “powerful” substance.

When consumed in greater doses, these two chemicals also have the ability to relax tight muscles, have anti-inflammatory properties, and induce drowsiness.

In conclusion, Kratom seems to be a multi-purpose medication.

Take a little amount and you’ll notice that you’re more invigorated. You’ll feel sedated if you take a lot. Kratom takes a few minutes to take effect in any case, and the effects might persist for hours.

If we apply the same logic to Modafinil, it seems that modest dosages of Kratom would be an excellent partner for improving cognitive function.

But is it scientifically sound to combine Kratom with Modafinil?

What Does Modafinil and Kratom Science Say?

Modafinil and Kratom seem to be dating in high school, like the awkward geek and the gorgeous cheerleader: Nobody could have predicted it from a mile away, but opposites do attract!

Let’s take a closer look at the science to determine whether this pairing is a match made in heaven.

Modafinil Advantages

  • Modafinil helps you think more clearly.

After reviewing 24 placebo-controlled trials published between 1990 and 2014 in healthy persons who were NOT sleep deprived, modafinil gained widespread prominence as a “smart medication” almost overnight[3].

Modafinil helps you make better judgments, plan ahead more successfully for the future, and perform better on lengthy and difficult activities.

Many individuals were concerned by the results; what if pupils suddenly had an unfair edge over the rest of the population?

Modafinil is categorized as a prohibited drug in international video gaming competitions… Some even have players submit to blood testing before they play.

Make no doubt about it: Modafinil is effective!

  • Pain-Induced Fatigue May Benefit From Modafinil

A patient with persistent discomfort in their lower back and neck, as well as extreme exhaustion, was the subject of an intriguing case report published in 2004.

When the patient was given Modafinil, they were able to utilize their lower back and neck more effectively while also feeling less tired.

One potential reason is that Modafinil helps with pain management indirectly by increasing alertness, which allows people to become more active.

  • Modafinil lowers the amount of mental energy required for tasks.

Have you ever felt absolutely overwhelmed when faced with a task? Something that seems easy on paper but proves to be too difficult to begin with?

Nothing crucial gets done because you’re in the “I don’t feel like it” attitude.

Modafinil reduces “analysis by paralysis” and gets you started on the work straight away, according to my experience and conversations with numerous digital nomads.

You may wonder how.

Because Modafinil boosts your wakefulness, you have more mental energy accessible to you.

And, since Modafinil improves attention, your whole energy is laser-focused on the job at hand.

It’s almost as if you’ve blown through an invisible wall of procrastination since your mental energy isn’t being squandered by thinking or fretting about anything else.

Benefits of Kratom

  • Pain Relief with Kratom

As previously said, the primary reason people use Kratom is for its pain-relieving properties. Kratom is a powerful “natural opioid” that many people claim helps them remain off pharmaceutical drugs.

While the FDA isn’t fond of it, there’s no disputing that Kratom has a devoted following, with many people using it on a daily basis to manage their pain.

  • Physical Fatigue Is Relieved by Kratom

Many people are unaware that manual workers in southern Thailand have used Kratom to combat weariness caused by working long hours in the hot sun[5].

What causes this to happen? One possible reason is that at the correct dosage, Kratom enhances blood flow and circulation, giving you greater energy to work harder and longer.

  • Kratom Can Assist You In Being More Social

This one is entirely based on accounts from other individuals, hence there are currently no scientific studies available.

After using Kratom, many individuals report feeling more at ease in social circumstances [6]. Their nervousness fades, and they find it much simpler to manage unknown situations.

It’s a lot better than depending on liquid courage when used properly and sensibly!

  • Kratom Could Make You Feel Happier

There are times when you just must meet deadlines, no matter how depressed you are.

While many individuals claim to feel less worried and sad after using Kratom, no human scientific investigations have confirmed this.

The antidepressant effect of Kratom in mouse models is currently the only scientific data we have in regard to Kratom and depression. [7]

Benefits of Taking Kratom and Modafinil Together

So, what precisely occurs when Modafinil and Kratom are combined?

It’s difficult to say since there are so few studies that look at their interactions, yet every Google search is replete with personal accounts from nootropic users.

But we can absolutely state the following with some degree of accuracy:

  • Modafinil and Kratom may help you strike a healthy balance between “working hard” and “playing hard.”

Remember this scene from the film The Wolf Of Wall Street?

“I take enough medications every day to numb Manhattan, Long Island, and Queens for a month.” I take Quaaludes 10-15 times a day for “back pain,” Adderall to keep focused, Xanax to relax, marijuana to relax, cocaine to wake me up, and morphine… Because it’s fantastic.”

In certain ways, Modafinil helps you stay focused while Kratom helps you relax. Which implies you should avoid taking both medications at the same time if you’re using them to balance each other out.

Before you start working, take your usual dosage of Modafinil and make sure you finish all of your critical chores.

Take a greater dosage of Kratom after you’re finished to produce a calm mood.

Because you need something to “fight” the long-lasting wakefulness caused by Modafinil, this combo should perform very well.

In layman’s terms, Kratom aids in the shift from hyper-focused to hyper-relaxed.

  • Together, modafinil and kratom can fight opioid addiction.

Modafinil may aid the recovery process for someone who is already taking Kratom to combat the symptoms of opioid withdrawal.

Higher dosages of Modafinil helped opiate-seeking rats that were addicted to morphine diminish the internal training that rendered them addicted to morphine in a research [8]:

“These data suggest that modafinil might be a potential preventative treatment for opiate addiction relapse in human addicts, while caution is advised.”

  • Modafinil and Kratom Can Help You Work 10x Harder

Before you scream at me for contradicting the very first advantage of mixing Kratom and Modafinil, hear me explain…

I said earlier in the text that combining Modafinil with a modest dosage of Kratom might conceivably result in a synergistic effect.

This means you’ll have even more attention and concentration than you would if you only took one of the nootropics.

This combination might possibly have a substantial influence on your everyday productivity, according to one person’s experience on the Shroomery Forum [9]:

“I’ve taken 600-700 mg of adrafinil with 1-3 tsp of white vein, green maeng da, or green borneo kratom on several occasions.” Everything has gone well, and I’m in a good mood. great energy, high drive, excellent for studying, hanging out, and just living. not convulsions or negative consequences.”

Modafinil and Kratom Side Effects

Kratom Modafinil side effects

Is it safe to take Modafinil and Kratom at the same time?

The answer is a resounding “no”. It is not safe to take Modafinil and Kratom at the same time. Mixing these substances can cause serious adverse effects, and no robust clinical trials have been done to examine the extent or severity of these side effects.

So although I describe Modafinil plus Kratom as an effective nootropic combination, there are some serious negative effects to be aware of.

Pay attention to some of these negative effects since they may make you reconsider your choice to combine Kratom and Modafinil.

  • Tonic-Clonic Convulsions

When your muscles alternate between rhythmic jerking (clonic) and immediate stiffening/contracting (tonic), you have a tonic-clonic seizure. It usually begins on both sides of your brain and is deadly if not treated promptly.

These seizures have been recorded in multiple hospital instances when Kratom and other medicines were used to deal with opiate withdrawal [10].

This is the first thing people say when Modafinil and Kratom are mentioned in the same phrase on any nootropics forum.

However, a closer examination of these studies reveals that several of the patients were already in poor condition (one was a 64-year-old man who was a very liberal drinker and smoker for most of his adult life).

This is the adverse effect you should be most concerned about!

  • Dry Mouth And Eyes

Modafinil and Kratom both have the tendency to dehydrate the person, which is an intriguing trait.

Because both nootropics cause your body to lose water, your eyes and mouth may feel particularly dry.

It wouldn’t surprise me if this effect was synergistic, therefore if you’re going to stack Kratom with Modafinil, I propose the following:

On the day you utilize both medications, drink AT LEAST a gallon of water (4 litres).

This is not an excessive quantity of water to consume in a 24-hour period, believe me.

Depending on how dehydrated you are, you may need to drink up to 6 litres (1.5 gallons) of water throughout the day.

  • Hypertension

While Kratom will not raise your blood pressure if taken sensibly, excessive usage at a high dosage will almost certainly induce hypertension (i.e. elevated blood pressure).

While Modafinil is one of the safest nootropics available, it may raise blood pressure in persons who are predisposed to heart disease.

If you’ve had trouble managing your blood pressure in the past, you should seek medical advice.

  • Nothing happens at all.

After reading many pages of thread comments, I believe this is a distinct possibility. If Modafinil and Kratom are used together, it’s probable that their beneficial effects may cancel one other out.

Some users have no reaction. Some people notice a tightness in their chest. And other folks spend their days feeling like they’re on “Cloud 9.”

As the famous Reddit term goes, “your mileage may vary.”

If you find yourself in this situation, there are two options to consider…

(1) Check out the Kratom strain you’re using.

Whether taken alone or in conjunction with Modafinil, the kind of Kratom you use may have a significant impact on the result you get.

The “Indo” strains, for example, are the most sedating, whilst the “Maeng da” variation serves as a stimulant [11].

(2) Check the amount of Kratom you’re taking.

To determine how much Kratom you should take, use the following scale:

  • Low dosages (1-5 grams) = Stimulant-like effects including decreased weariness and improved attention.
  • Moderate dosages (5-15 grams) result in a mild “high” as well as pain alleviation.
  • High doses (>15 grams) = Sedation, but a much higher risk of major side effects like dizziness and nausea
Please remember that we are not doctors and this is not medical advice. Modafinil and Kratom are not substances we recommend taking at the same time in any situation. The chances of experiencing side effects from Modafinil and Kratom stacks is very high, and the combination is likely to produce counter-productive effects. Talk to your doctor before you take either of these substances in isolation or together.

Conclusion: Should you mix Modafinil and Kratom?

The combination of modafinil and Kratom is one that leaves you with no clear response.

You’ll have to try it out and see whether it works for you when it comes to how they may improve your day-to-day performance.

Your reaction will be completely unique to you, and it will not necessarily mirror that of other nootropic users.

So, if you’re reading this and are very certain you want to stack Kratom and Modafinil, you should buy them from reputable sources.

This detailed guide assesses every genuine Modafinil site on the internet and recommends where you should spend your hard-earned cash.

In terms of Kratom, I’m not sure how long my American readers will be able to get their hands on it since the DEA wants to declare it a Schedule I restricted narcotic.

Fair warning: Make sure you verify your country’s state/federal regulations to make sure you may own and use Kratom legally.

Get your hands on the most potent smart medicine on the planet…Modafinil!

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Modafinil & Kratom FAQs

What can you not mix with Modafinil?

You should not mix Modafinil with other drugs, including alcohol, anti-depressants, Adderall, Vyvanse, and other potent mind-altering substances. We also advise you to avoid mixing Modafinil with grapefruit, as this has been proven to reduce the efficacy of Modafinil.

What drugs does Modafinil interact with?

Modafinil is a powerful eugeroic and as such it interacts with many other drugs and nootropics, including: Adderall, Vyvanse, Strattera, Aniracetam, Noopept, Caffeine, Nicotine, Xanax, Benadryl, and many other compounds including anti-depressants, sleeping pills and anti-anxiety medication.

Can I take Modafinil with Xanax?

No you should not take Modafinil with Xanax. You may have undesired reactions if you take modafinil along with diazepams (such as Xanax or Ativan) or antidepressants.


  1. Modafinil. (accessed January 25, 2020).
  2. Kratom: Horrible foliage or useful plant? The date is January 26, 2020.
  3. Modafinil, the “smart drug,” is indeed effective, according to research. The date is January 26, 2020.
  4. Modafinil for the treatment of pain-related fatigue: a review and case report, Fishbain DA, Cutler RB, Lewis J, et al. 2004;18(2):39-47 in J Pain Palliat Care Pharmacother. doi:10.1080/J354v18n02 04
  5. E. Cinosi, G. Martinotti, P. Simonato, and others Following “the Roots” of Kratom (Mitragyna speciosa): The Evolution of an Enhancer from a Traditional Southeast Asian Use to a Recreational Psychoactive Drug in Western Countries 2015;2015:968786 Biomed Res Int. doi:10.1155/2015/968786
  6. New Drugs of Abuse. Rech MA, Donahey E, Cappiello Dziedzic JM, et al. doi:10.1002/phar.1522. Pharmacotherapy. 2015 Feb;35(2):189-97.
  7. NF Idayu, MT Hidayat, MA Moklas, et al. Mitragynine extracted from Mitragyna speciosa Korth has an antidepressant-like effect in a mouse depression model. doi:10.1016/j.phymed.2010.08.011. Phytomedicine. 2011 Mar 15;18(5):402-7.
  8. P Tahsili-Fahadan, GV Carr, GC Harris, and others Modafinil prevents rats from resuming their opiate-seeking behavior, according to a glutamate-mediated mechanism. doi:10.1038/npp.2010.94. Neuropsychopharmacology. 2010 Oct;35(11):2203-10.
  9. Is it safe to combine modafinil with kratom? Self-experimentation. The date is January 26, 2020.
  10. S. Likhitsathian, W. Jiraporncharoen, A. Aramrattana, and others. J Subst Usage. 2018 Feb;23(4):384-389. Polydrug use among kratom users: Findings from the 2011 Thailand National Household Survey. doi:10.1080/14659891.2018.1436599
  11. Is Kratom Effective for Depression and Anxiety?, retrieved January 26, 2020.

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About P. Tardner

Paul Tardner is the Lead Author at Paul is a former academic and research scientists. He now dedicates his time to his own research into natural biohacking, with a particular focus on cognitive enhancement.

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