Modafinil, as many of you will no doubt be aware, is one of the most popular cognitive enhancers in the world. As a pharmaceutical drug, it is used to treat sleeping disorders like narcolepsy. However, it is also the prototypical nootropic, and tens of thousands of people around the world use it daily to enhance their cognitive performance.
Kratom (Mitragyna speciosa), by contrast, is a plant frequently used as a recreational drug due to its opiate-like effects. A tropical tree in the coffee family, Kratom is native to South East Asia where it is widely consumed recreationally.
What Modafinil and kratom do have in common is that they are both incredibly popular in the Western world. The use of both Modafinil and Kratom has increased dramatically in recent years, and the trend appears likely to continue upwards for some time.
One worrying trend is for people to take Kratom and Modafinil at the same time. Mixing Modafinil with Kratom may seem like a good idea on paper – combining an upper with a downer – but it is not something we would recommend! In this article, we explain why mixing Kratom with Modafinil is not a good idea.
What is the safest Modafinil brand for stacking?
We strongly advise against stacking Modafinil with other psychoactive drugs, including Kratom. However, if you are going to stack Modafinil with other substances, we urge you to invest in the highest quality Modafinil that you possibly can to try and minimize side effect risks as much as possible.
So what is the best brand of Modafinil for stacking?
The answer is that it doesn’t really matter what specific Modafinil brand you decide to use so long as you bought it from a reputable online pharmacy with a long track record of delivering pure, clean, potent product.
We recommend using Modafinil XL. This is a vendor we have used for dozens of orders, and they have a strong reputation as a seller of extremely high quality Modafinil at the lowest prices on the market.
What exactly is Modafinil?
Allow me to refresh your memory on Modafinil in case you’ve never heard of it before…
Modafinil is a prescription medicine that promotes wakefulness and was licensed by the FDA in December 1998 for the treatment of narcolepsy. As it increases wakefulness and fends off sleep without acting as a stimulant, Modafinil is classed as a ‘eugeroic’.
What is a Eugeroic?
If you’ve never come across the term ‘eugeroic’ before, you’re not alone. While this word is rarely used in day-to-day life, it is a key category of nootropics of which Modafinil is the prototypical example.
A eugeroic is a substance which promotes wakefulness, prevents sleep and increases alertness. These are typically used to treat sleep disorders such as narcolepsy or excessive daytime sleepiness. Importantly, eugeroics are not psychostimulants like methylphenidate or Adderall; they do not work by exciting the CNS, they do not produce any kind of stimulant ‘high’, and as such, they carry a far lower risk of addiction and side effects.
Other Benefits of Modafinil
Besides narcolepsy, Modafinil has been prescribed for shift work sleep disorder and obstructive sleep apnea. Basically, any situation in which the patient’s excessive drowsiness is a significant problem.
People have learned that Modafinil can accomplish so much more since 1998.
Several healthy people, particularly those in high-stress occupations, discovered that Modafinil may significantly improve the intensity and length of their focus.
Modafinil is now well-known for its off-label uses, which include assisting individuals in getting “things” done better and quicker while outworking their opponents.
And how does this nootropic function in your brain? Researchers who have been examining this medicine for many decades are unsure.
Modafinil enhances dopamine (the “feel good” neurotransmitter) in the brain by delaying its breakdown, according to research.
This explains why Modafinil users experience such a strong rush of motivation after taking it.
With this in mind, why would anybody consider combining Modafinil and Kratom? To answer that question, we first need to find out what Kratom is and what it does to the brain.
What exactly is Kratom?
To understand why mixing Kratom and Modafinil is both so common and such a terrible idea, we need to look at the pharmacology and pharmacokinetics of Kratom and its active components.
Kratom, also known as Mitragyna speciosa, is a tropical tree native to Indonesia, Thailand, and other Southeast Asian nations. It goes by numerous names in those nations, including “Ketum” and “Thom.”
The leaf extracts have been used in traditional medicine for hundreds of years to treat digestive issues, exhaustion, discomfort, and a variety of other diseases.
However, its use has changed dramatically since then. Today, you’ll see that many individuals are utilizing it as a recreational substance to experience a different kind of high.
At the same time, many medical patients recommend Kratom as a helpful strategy to alleviate chronic pain and narcotic withdrawal symptoms.
So, how does Kratom function?
Kratom’s effects are attributed to two main active ingredients:
Many people think Kratom works as an opiate because both of these chemicals connect to the primary opioid receptors located in our brain and spinal cord.
Kratom’s pain-relieving properties are delivered to the user in this way.
It’s worth mentioning that powerful opioids like morphine, fentanyl, and others bind to the same receptors. However, they bind to these receptors 10-100 times more strongly than mitragynine or 7-hydroxymitragynine, making it misleading to label Kratom as a “powerful” substance.
When consumed in greater doses, these two chemicals also have the ability to relax tight muscles, have anti-inflammatory properties, and induce drowsiness.
In conclusion, Kratom seems to be a multi-purpose medication.
Take a little amount and you’ll notice that you’re more invigorated. You’ll feel sedated if you take a lot. Kratom takes a few minutes to take effect in any case, and the effects might persist for hours.
If we apply the same logic to Modafinil, it seems that modest dosages of Kratom would be an excellent partner for improving cognitive function.
But is it scientifically sound to combine Kratom with Modafinil?
What Does The Science Say About Mixing These Drugs?
What does the clinical literature have to say about mixing Modafinil and Kratom?
Let’s take a closer look at the science to determine whether this pairing is a match made in heaven or a disastrous idea. Here is a quick overview of the clinially proven benefits of both drugs when taken in isolation.
Modafinil helps you think more clearly.
After reviewing 24 placebo-controlled trials published between 1990 and 2014 in healthy persons who were NOT sleep deprived, modafinil gained widespread prominence as a “smart medication” almost overnight.
Modafinil helps you make better judgments, plan ahead more successfully for the future, and perform better on lengthy and difficult activities.
Many individuals were concerned by the results; what if pupils suddenly had an unfair edge over the rest of the population?
Modafinil is categorized as a prohibited drug in international video gaming competitions… Some even have players submit to blood testing before they play.
Make no doubt about it: Modafinil is effective!
Pain-Induced Fatigue May Benefit From Modafinil
A patient with persistent discomfort in their lower back and neck, as well as extreme exhaustion, was the subject of an intriguing case report published in 2004.
When the patient was given Modafinil, they were able to utilize their lower back and neck more effectively while also feeling less tired.
One potential reason is that Modafinil helps with pain management indirectly by increasing alertness, which allows people to become more active.
Modafinil lowers the amount of mental energy required for tasks.
Have you ever felt absolutely overwhelmed when faced with a task? Something that seems easy on paper but proves to be too difficult to begin with?
Nothing crucial gets done because you’re in the “I don’t feel like it” attitude.
Modafinil reduces “analysis by paralysis” and gets you started on the work straight away, according to my experience and conversations with numerous digital nomads.
You may wonder how.
Because Modafinil boosts your wakefulness, you have more mental energy accessible to you.
And, since Modafinil improves attention, your whole energy is laser-focused on the job at hand.
It’s almost as if you’ve blown through an invisible wall of procrastination since your mental energy isn’t being squandered by thinking or fretting about anything else.
Benefits of Kratom
Pain Relief with Kratom
As previously said, the primary reason people use Kratom is for its pain-relieving properties. Kratom is a powerful “natural opioid” that many people claim helps them remain off pharmaceutical drugs.
While the FDA isn’t fond of it, there’s no disputing that Kratom has a devoted following, with many people using it on a daily basis to manage their pain.
Physical Fatigue Is Relieved by Kratom
Many people are unaware that manual workers in southern Thailand have used Kratom to combat weariness caused by working long hours in the hot sun.
What causes this to happen? One possible reason is that at the correct dosage, Kratom enhances blood flow and circulation, giving you greater energy to work harder and longer.
Kratom Can Assist You In Being More Social
This one is entirely based on accounts from other individuals, hence there are currently no scientific studies available.
After using Kratom, many individuals report feeling more at ease in social circumstances . Their nervousness fades, and they find it much simpler to manage unknown situations.
It’s a lot better than depending on liquid courage when used properly and sensibly!
Kratom Could Make You Feel Happier
There are times when you just must meet deadlines, no matter how depressed you are.
While many individuals claim to feel less worried and sad after using Kratom, no human scientific investigations have confirmed this.
The antidepressant effect of Kratom in mouse models is currently the only scientific data we have in regard to Kratom and depression. 
Benefits of Taking Kratom and Modafinil Together
So, what precisely occurs when Modafinil and Kratom are combined?
It’s difficult to say since there are so few studies that look at their interactions, yet every Google search is replete with personal accounts from nootropic users.
But we can absolutely state the following with some degree of accuracy:
Modafinil and Kratom may help you strike a healthy balance between “working hard” and “playing hard.”
Remember this scene from the film The Wolf Of Wall Street?
“I take enough medications every day to numb Manhattan, Long Island, and Queens for a month.” I take Quaaludes 10-15 times a day for “back pain,” Adderall to keep focused, Xanax to relax, marijuana to relax, cocaine to wake me up, and morphine… Because it’s fantastic.”
In certain ways, Modafinil helps you stay focused while Kratom helps you relax. Which implies you should avoid taking both medications at the same time if you’re using them to balance each other out.
Before you start working, take your usual dosage of Modafinil and make sure you finish all of your critical chores.
Take a greater dosage of Kratom after you’re finished to produce a calm mood.
Because you need something to “fight” the long-lasting wakefulness caused by Modafinil, this combo should perform very well.
In layman’s terms, Kratom aids in the shift from hyper-focused to hyper-relaxed.
Together, modafinil and kratom can fight opioid addiction.
Modafinil may aid the recovery process for someone who is already taking Kratom to combat the symptoms of opioid withdrawal.
Higher dosages of Modafinil helped opiate-seeking rats that were addicted to morphine diminish the internal training that rendered them addicted to morphine in a research :
“These data suggest that modafinil might be a potential preventative treatment for opiate addiction relapse in human addicts, while caution is advised.”
Modafinil and Kratom Can Help You Work 10x Harder
Before you scream at me for contradicting the very first advantage of mixing Kratom and Modafinil, hear me explain…
I said earlier in the text that combining Modafinil with a modest dosage of Kratom might conceivably result in a synergistic effect.
This means you’ll have even more attention and concentration than you would if you only took one of the nootropics.
This combination might possibly have a substantial influence on your everyday productivity, according to one person’s experience on the Shroomery Forum :
“I’ve taken 600-700 mg of adrafinil with 1-3 tsp of white vein, green maeng da, or green borneo kratom on several occasions.” Everything has gone well, and I’m in a good mood. great energy, high drive, excellent for studying, hanging out, and just living. not convulsions or negative consequences.”
Modafinil and Kratom Side Effects
Is it safe to take Modafinil and Kratom at the same time?
The answer is a resounding “no”. It is not safe to take Modafinil and Kratom at the same time. Mixing these substances can cause serious adverse effects, and no robust clinical trials have been done to examine the extent or severity of these side effects.
So although I describe Modafinil plus Kratom as an effective nootropic combination, there are some serious negative effects to be aware of.
Pay attention to some of these negative effects since they may make you reconsider your choice to combine Kratom and Modafinil.
When your muscles alternate between rhythmic jerking (clonic) and immediate stiffening/contracting (tonic), you have a tonic-clonic seizure. It usually begins on both sides of your brain and is deadly if not treated promptly.
These seizures have been recorded in multiple hospital instances when Kratom and other medicines were used to deal with opiate withdrawal .
This is the first thing people say when Modafinil and Kratom are mentioned in the same phrase on any nootropics forum.
However, a closer examination of these studies reveals that several of the patients were already in poor condition (one was a 64-year-old man who was a very liberal drinker and smoker for most of his adult life).
This is the adverse effect you should be most concerned about!
Dry Mouth And Eyes
Modafinil and Kratom both have the tendency to dehydrate the person, which is an intriguing trait.
Because both nootropics cause your body to lose water, your eyes and mouth may feel particularly dry.
It wouldn’t surprise me if this effect was synergistic, therefore if you’re going to stack Kratom with Modafinil, I propose the following:
On the day you utilize both medications, drink AT LEAST a gallon of water (4 litres).
This is not an excessive quantity of water to consume in a 24-hour period, believe me.
Depending on how dehydrated you are, you may need to drink up to 6 litres (1.5 gallons) of water throughout the day.
While Kratom will not raise your blood pressure if taken sensibly, excessive usage at a high dosage will almost certainly induce hypertension (i.e. elevated blood pressure).
While Modafinil is one of the safest nootropics available, it may raise blood pressure in persons who are predisposed to heart disease.
If you’ve had trouble managing your blood pressure in the past, you should seek medical advice.
Nothing happens at all.
After reading many pages of thread comments, I believe this is a distinct possibility. If Modafinil and Kratom are used together, it’s probable that their beneficial effects may cancel one other out.
Some users have no reaction. Some people notice a tightness in their chest. And other folks spend their days feeling like they’re on “Cloud 9.”
As the famous Reddit term goes, “your mileage may vary.”
If you find yourself in this situation, there are two options to consider…
(1) Check out the Kratom strain you’re using.
Whether taken alone or in conjunction with Modafinil, the kind of Kratom you use may have a significant impact on the result you get.
The “Indo” strains, for example, are the most sedating, whilst the “Maeng da” variation serves as a stimulant .
(2) Check the amount of Kratom you’re taking.
To determine how much Kratom you should take, use the following scale:
- Low dosages (1-5 grams) = Stimulant-like effects including decreased weariness and improved attention.
- Moderate dosages (5-15 grams) result in a mild “high” as well as pain alleviation.
- High doses (>15 grams) = Sedation, but a much higher risk of major side effects like dizziness and nausea
Conclusion: Should you mix Modafinil and Kratom?
The combination of modafinil and Kratom is one that can produce completely unpredictable results. These drugs have ver different mechanisms of action and wildly different sets of side effects. Taking Modafinil with Kratom or any other drugs with opiate effects is going to cause problems.
Your reaction to mixing these drugs will be completely unique to you, and it will not necessarily mirror that of other nootropic users.
In terms of Kratom, I’m not sure how long my American readers will be able to get their hands on it since the DEA wants to declare it a Schedule I restricted narcotic.
Fair warning: Make sure you verify your country’s state/federal regulations to make sure you may own and use Kratom legally.
So, if you’re reading this and are very certain you want to stack Kratom and Modafinil, you should buy them from reputable sources. We strongly recommend you check out Modafinil XL. These guys sell pharmaceutical-grade Modafinil products for rock bottom prices.
Click the image below to get an exclusive deal on Modalert (the world’s most popular generic Modafinil brand) for a limited time only!
Modafinil & Kratom FAQs
What can you not mix with Modafinil?
You should not mix Modafinil with other drugs, including alcohol, anti-depressants, Adderall, Vyvanse, and other potent mind-altering substances. We also advise you to avoid mixing Modafinil with grapefruit, as this has been proven to reduce the efficacy of Modafinil.
What drugs does Modafinil interact with?
Modafinil is a powerful eugeroic and as such it interacts with many other drugs and nootropics, including: Adderall, Vyvanse, Strattera, Aniracetam, Noopept, Caffeine, Nicotine, Xanax, Benadryl, and many other compounds including anti-depressants, sleeping pills and anti-anxiety medication.
Can I take Modafinil with Xanax?
No you should not take Modafinil with Xanax. You may have undesired reactions if you take modafinil along with diazepams (such as Xanax or Ativan) or antidepressants.
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- Is it safe to combine modafinil with kratom? Self-experimentation. The date is January 26, 2020. Shroomery.org
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Paul Tardner is the Head Writer at IJEST.org. Paul is a former academic and research scientist. He now dedicates his time to his own research into nootropics, with a particular focus on cognitive enhancement in old age. You can learn more about Paul from his profile page.