Focus, Learning & Memory
Neuroplasticity & Brain Health
Value For Money
Noocube is essentially the UK’s answer to Alpha Brain; the formula is clearly designed to mimic the older nootropic, and it actually improves on it considerably. But Noocube is still far from a good nootropic. Just 50mg of cholinergic is nowhere near enough for a modern brain supplement. There’s more than one useless ingredient in Noocube too. Better brain supplements are available.
Compare with our current top rated nootropic: https://www.ijest.org/nootropics/mind-lab-pro-review/
Contains a decent serving of Tyrosine
Contains 250mg of 20% Bacoside Bacopa monnieri
Provides just 50mg of Alpha-GPC, which is a pathetic dose
Contains several useless, unproven ingredients
Uses fairly standard ingredient forms; no enhanced bioavailability
What Is Noocube?
Noocube is one of the most popular nootropics in the world. Although it has been on the market for some time, it has remained popular, despite a lot of negative Noocube reviews and less than flattering chatter on nootropic forums. How has this nootropic remained so popular in the face of so many negative reviews?
According to the Noocube website, this nootropic can:
- Heighten concentration
- Increase focus
- Improve memory
- Promote learning
- Reduce stress and anxiety
That is a very ambitious product. With the exception of supporting brain health and promoting neuroplasticity, this is pretty much everything you can expect from a good nootropic.
But does Noocube really work? Is it safe? Will it cause side effects? What is in Noocube? Are there better nootropics on offer right now? Read the detailed Noocube review below and find out! Alternatively, read our Mind Lab Pro review to compare to our current top rated nootropic.
Here is the Noocube ingredients list:
In case that mage doesn’t appear, here is a list of the Noocube ingredients with doses:
- Vitamin B1 – 1.1mg
- Vitamin B7 – 50mcg
- Vitamin B12 – 2.5mcg
- Bacopa monnieri -250g
- L-Tyrosine – 250mg
- Cat’s claw extract – 175mg
- Oat straw extract – 150mg
- L-Theanine – 100mg
- Alpha-GPC – 50mg
- Huperzia serrata (0.5% Huperzine A) – 20mg
- Lutemax 2020® – 20mg
- Resveratrol 99% – 14.3mg
- Pterostilbene – 140mcg
We’ll now go through each Noocube ingredient one-by-one, explaining what the substance does, what the clinical data says, and what we make of the dose. Then we’ll give you our verdict on the Noocube formula as a whole.
B Vitamins – 100% RDI
B vitamins are essential nutrients which play a key part in the energy metabolism process. Increasing B vitamin intake raises energy levels in a deep, sustained way. B vitamins are also needed for the creation of blood cells, nerve cells, and brain cells. While B vitamin deficiencies are incredibly rare, supplementing with B vitamins does yield benefits. These are good ingredients to have in a daily nootropic like Noocube, although they wont have a noticeable effect on cognition.
Bacopa monnieri -250g
Bacopa monnieri is an incredible cognitive enhancer. Several clinical trials have shown that Bacopa monnieri supplementation drastically improves scores on memory tests in just 6-12 weeks. Older people and people with mild cognitive impairment seem to respond best to Bacopa monnieri, although otherwise healthy people show marked improvements in memory retention and recall after 12 weeks of consistent Bacopa use.
Noocube provides 250mg of Bacopa monnieri per serving. This is a solid dose, although the extract quality is substandard. We’d prefer less Bacopa but a more Bacoside-rich extract.
L-Tyrosine – 250mg
Tyrosine is one of our favorite nootropics. It is easily one of the most effective, and most overlooked, cognitive enhancers in use today. Tyrosine improves stress resistance and protects cognitive function in stressful situations. Studies have shown that Tyrosine improves cognitive performance generally in people exposed to acute stressors, including sleep deprivation. The 250mg of Tyrosine we get from Noocube is more than enough to see benefits.
Cat’s claw extract – 175mg
Cat’s claw is used in some traditional medicines as a general curative. Lots of people claim that supplementing with Cat’s Claw helps with a wide range of ailments, including viruses, ulcers, and other infections. We have seen no evidence to support these claims. We have certainly never seen evidence which supports the idea that Cat’s Claw enhances cognition in any way.
Cat’s claw is not a common ingredient in nootropic stacks today. The only other popular brain supplement which uses this stuff is Alpha Brain; this is a recurring theme with Noocube, which we’ll discuss later!
Oat straw extract – 150mg
A number of supplement manufacturers have been making some pretty spectacular claims about oat straw lately. Some claim that it reduces inflammation, while others suggest that it can improve mood and improve cognitive performance. As it stands, we have not seen any compelling studies which prove that oat straw consumption enhances cognitive performance.
Oat Straw is another unusual nootropic ingredient, and it is another ingredient that both Noocube and Alpha Brain share! What a coincidence! How much Oat Straw is in Noocube doesn’t really matter as no amount is thought to have nootropic effects.
L-Theanine – 100mg
Theanine is an amino acid found in large quantities in black tea. Theanine has several interesting effects on the body. It has been included in Noocube is no doubt because of its synergistic relationship with caffeine. Thenaine amplifies the beneficial effects of caffeine while simultaneously dampening its negative effects. Theanine thus allows you to enjoy the heightened focus and increased energy of caffeine with less of the jitters and anxiety that come with it. It also promotes restful sleep and has mild cognitive-enhancing effects of its own, although these are mild.
Noocube provides 100mg of Theanine, which is enough to take the edge off your morning coffee and give you a sustained, lasting buzz free of jitters.
Alpha-GPC – 50mg
Alpha-GPC is a cholingeric, and an extremely efficient one at that. Alpha-GPC rapidly increase choline availability in the brain, which in turn raises both acetylcholine and phosphatidylcholine levels. More acetylcholine means more raw brain power, while more phosphatidylcholine means better brain cell maintenance and more effective memory formation.
The sad thing here is that Noocube provides a pathetically small dose of Alpha-GPC. The best nootropics will typically include anywhere from 200mg to 600mg of Alpha-GPC (or an alternative cholinergic). Noocube contains just 50mg, which is unlikely to produce any of the amazing benefits associated with Alpha-GPC consumption.
Huperzia serrata (0.5% Huperzine A) – 20mg
Huperzia serrata is the only natural source of a nootropic compound called Huperzine A. Huperzine A inhibits the action of an enzyme called acetylcholinesterase. This enzyme gets rid of acetylcholine – the brain’s executive neurotransmitter – once it has been used to send a signal between neurons. By inhibing the enzyme, Huperzine A supplementation causes a steady build-up of acetylcholine in the brain, which means greater executive cognitive capacity (i.e. more focus, faster decision-making, and better working memory).
However, we don’t like seeing Huperzine A in a daily nootropic stack like Noocube. Huperzine A must be cycled; if you don’t take regular breaks, your acetylcholine levels will get out of control and you will experience side effects. This is poor formula creation on Noocube’s part!
Lutemax 2020® – 20mg
We have no idea why this Noocube ingredient is here. Lutemax is a branded vision supplement – it is a combination of lutein and zeaxanthin, which enhance eyesight and promote eye health. These two substances have no nootropic effects at all. The makers of Noocube might think having better vision is a great thing, so why would we not want it in a supplement? The answer is, we want to decide what our supplements do; when we buy a dedicated nootropic stack, we want cognitive enhancement and nothing else! It’s crazy to us that Noocube have included such an expensive irrelevant ingredient.
Resveratrol 99% – 14.3mg + Pterostilbene – 140mcg
Resveratrol is an antioxidant. It is found in relatively large quantities in grapes, blueberries, raspberries and mulberries (specifically in the skin of these fruits). Pterostilbene is demethylated derivative of resveratrol that is considered more potent. We prefer manufacturers to use pterostilbene rather than resveratrol. Using both seems cheap and pointless.
Having a healthy antioxidant profile at all times is a good way to ensure overall good health, and an excellent way to support cognitive function as you get older. Oxidative damage slowly degrades brain cells over time, inhibiting their function. Since so few of us consume fresh fruits, vegetables, and green tea every day, supplementing with extra antioxidants is a good idea for optimal brain health.
Our verdict: Does Noocube really work?
Does Noocube really work? Is it really one of the best nootropics on the market?
The answer is no, we don’t think much of Noocube at all.
We think it’s pretty clear that Noocube is a kind of diluted version of Alpha Brain, admittedly with a more transparent formula.
It uses some of the same ingredients as Alpha Brain. But curiously, it copies some of the completely useless ingredients you find in Alpha Brain. We don’t see why you would include those ingredients – which have no nootropic properties – if you weren’t copying off an already popular nootropic supplement!
Aside from that, there are serious problems with the Noocube formula.
Noocube contains Huperzine A, which needs to be regularly cycled. Taking constant breaks from your daily nootropic stack is not ideal; it means you’ll never fully benefit from things like Alpha-GPC or Bacopa monnieri.
Noocube also provides a pretty pathetic dose of Alpha-GPC. Every good brain supplement today provides a large dose of a potent cholinergic. The best nootropics today typically contain 300mg of Alpha-GPC, or 200mg of Citicoline. The 50mg of Alpha-GPC we get from this stack is nowhere near enough for you to see benefits.
Then there’s all the useless garbage in the Noocube formula. Lutemax is a vision enhancer. Oat straw doesn’t do anything for cognitive function, and cat’s claw has never been proven to do anything at all!
All-in-all, Noocube is a pretty terrible nootropic supplement.
We think it has become so popular purely because it is a kind of cheaper version of Alpha Brain.
If you want a supplement that is going to provide top-to-bottom, complete brain optimization, Noocube is not it. There are far more comprehensive nootropics on sale right now, offering better ingredient quality and far more bang for your buck. Our current top rated nootropic, Mind Lab Pro, is a prime example.
Noocube side effects: Is it safe?
Is Noocube safe? Will it cause side effects?
Unfortunately the answer is yes, we think Noocube is highly likely to cause side effects if it is used on a daily basis for a prolonged period of time. This is due to the presence of Huperzine A in the Noocube formula.
As explained in the ingredients section, Huperzine A inhibits the enzyme acetylcholinesterase. This causes a steady build-up of acetylcholine in the brain. While this is good in the short-term, if acetylcholine levels get too high, you will start to experience a range of serious side effects.
These side effects include:
- Loss of focus
- Lack of motivation
- Muscle cramps
- Muscle spasms
If it vital that you give yourself a cooldown period where your acetylcholine levels fall back down to within normal limits. This typically means using Huperzine A for no longer than 2-3 weeks at a time, before taking a similar amount of time off.
Noocube doesn’t recommend this regimen. In fact, Noocube is advertised as a complete, daily nootropic. This is irresponsible in our opinion. Using Noocube daily will cause side effects!
Noocube review conclusion: Is it a good nootropic?
If you’ve read the full Noocube review above, you’ll know that we are not big fans of this brain supplement. Given the popularity of Noocube, we really were expecting a lot more.
This nootropic is a major disappointment.
Viewed objectively, Noocube looks like a cheap rip-off of Alpha Brain rather than a solid nootropic supplement in its own right.
There are lots of problems with Noocube. The most serious is probably the use of unproven and ineffective ingredients. Each serving of Noocube contains several hundred milligrams of completely useless ingredients, such as Oat Straw and Cat’s Claw. Neither of these substances offer any notable benefits at all, let alone significant enhancements in cognitive function!
The use of two antioxidants that are practically identical – with one being slightly more powerful than the other – is also lazy, wasteful, and cheap.
Then there’s the tiny dose of Alpha-GPC. At 50mg per serving, the makers of Noocube may as well have just left that cholinergic out. Every good nootropic on sale today offers a healthy dose of a potent cholinergic, whereas Noocube does not.
The fact that you need to be constantly taking breaks from Noocube because of the Huperzine A just caps this all off for us; this is not a good nootropic at all.
If you’re looking for a complete, daily nootropic stack for total brain optimization, Noocube is not it!
Paul Tardner is the Head Writer at IJEST.org. Paul is a former academic and research scientist. He now dedicates his time to his own research into nootropics, with a particular focus on cognitive enhancement in old age. You can learn more about Paul from his profile page.