Vyvanse and Adderall are essentially the same drug once you look under the hood. All that separates them is their names and how they are marketed. Adderall and Vyvanse are actually brand names for the (usually) same collection of amphetamine salts. These salts are combined to both maximize effects and prolong the action fo the drugs, giving potent and extended relief to people with ADHD or ADD.

Is it a good idea then to take Vyvanse and Adderall together at the same time?

A lot of people – especially young people who use Adderall on a daily basis – wonder whether stacking Adderall and Vyvanse might make both drugs even more powerful.

You should be very careful when taking Vyvanse and Adderall, as they can interact with other medicines. You should let your doctor know if you are on any anti-depressants or any other kind of medicine that could interact with Vyvanse. Also, you should tell your doctor about any other medicines you are taking, such as psychiatric medicines or even over-the-counter Adderall substitutes. Your list of medicines should be complete and updated. If you decide to take Vyvanse and Adderall together, make sure to take your Adderall as directed. Your doctor may need to adjust your dose.

In this article, we’ll look at the dangers and benefits of taking Vyvanse and Adderall together. In the end, we’ll tell you whether or not we think this is something anyone should ever do.


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Does It Make Sense To Take Adderall With Vyvanse?

At first glance, one might wonder why anyone would want to combine two stimulant medications, Adderall and Vyvanse. Both drugs are frequently prescribed to treat Attention Deficit Hyperactivity Disorder (ADHD), with each having its unique properties. But taking them together? Let’s dive into the science, but in a chit-chat manner, so we’re on the same page.

The Science Behind the Drugs

Adderall is a mix of amphetamine salts that work by increasing the release of neurotransmitters like dopamine and norepinephrine in the brain. It’s a bit like giving your brain a caffeine jolt, but more potent and specific. Vyvanse, on the other hand, contains lisdexamfetamine, which the body converts into dextroamphetamine. The unique thing about Vyvanse is its prodrug nature: it gets metabolized into its active form only after ingestion, resulting in a smoother onset and potentially longer duration of action.

Why Mix Them?
Some might think of combining the two to either enhance the overall effect or cover parts of the day when one medication wears off, and the other can take over. Imagine having a slow-release caffeine drink and then sipping on espresso shots for an extra kick when needed. That’s the rationale some might have.

But does it make sense to mix the ADHD medications?

From a medical perspective, combining two stimulants can be dicey. Overlapping the effects could increase the risk of side effects like increased heart rate, hypertension, anxiety, and insomnia. The synergy might not always lead to better focus; it can sometimes cause overstimulation or increased agitation.

Further, there’s no concrete research showing any consistent benefit of combining these drugs over using them separately. In fact, the risks might outweigh potential benefits for most individuals.

While the idea of blending the effects of Adderall and Vyvanse might sound tempting for extended or enhanced focus, the potential dangers make this a conversation to have with a medical professional. Self-experimentation without proper guidance could lead to adverse health outcomes. Always prioritize safety and evidence-based practices.


Side Effects of Taking Vyvanse and Adderall Together

Both Vyvanse and Adderall are central nervous system stimulants, and each is prescribed for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). While they have proven to be effective in managing ADHD symptoms, they also come with their own set of side effects. When combined, the risk of experiencing these side effects intensifies, and there may also be the potential for new adverse reactions. Below, we delve into the side effects that might arise from stacking these two drugs.

Potential Side Effects:

  • Increased Heart Rate: Both Vyvanse and Adderall can raise the heart rate. When combined, there’s a risk of tachycardia, or an abnormally fast heart rate. Over time, this can place undue stress on the cardiovascular system.
  • High Blood Pressure: Stimulants are known to raise blood pressure. Taking two stimulants at once can amplify this effect, posing significant risks, especially to those with pre-existing hypertension or cardiovascular diseases.
  • Overstimulation: This can manifest as increased anxiety, restlessness, or jitteriness. Think of it as having one too many coffees – your brain is in overdrive, and calming down becomes a challenge.
  • Sleep Disturbances: As stimulants, both medications can interfere with sleep patterns. Taken together, they could lead to pronounced insomnia or disrupted sleep.
  • Digestive Issues: These could include nausea, loss of appetite, and stomach upset. Both medications can affect appetite and digestion individually, and when combined, these effects could intensify.
  • Mood Fluctuations: This could range from irritability to mood swings and even depressive episodes. The combination might amplify emotional responses and mood changes.
  • Potential for Addiction: Stimulants have a potential for abuse and addiction. Combining two potent stimulants can increase the risk of developing a substance use disorder.
  • Aggravation of Mental Health Disorders: If someone has an underlying or undiagnosed mental health disorder, such as bipolar disorder, the combination can exacerbate symptoms or trigger manic episodes.
  • Increased Risk of Cardiovascular Events: There’s a potential for severe cardiovascular events, including stroke or heart attack, especially in those with existing risk factors.
  • Neurological Symptoms: This includes headaches, dizziness, and tremors. The brain is receiving a double dose of stimulants, which can lead to pronounced neurological effects.

It’s also worth noting that the side effects might not be limited to the ones listed above. Everyone’s body reacts differently, and unique reactions might occur based on an individual’s physiology, other medications taken, underlying health conditions, and lifestyle factors like diet and exercise.

While many people are prescribed either Vyvanse or Adderall and benefit from their therapeutic effects, combining the two poses risks that are not fully understood. The side effects of one drug might magnify those of the other, leading to heightened discomfort or risk. Additionally, there’s a lack of comprehensive research on the outcomes of taking both stimulants concurrently.

Moreover, the dosages play a crucial role. A lower dose of each might result in milder side effects, while higher doses can result in more pronounced and potentially dangerous outcomes. Stacking the two might also alter the duration of action of each drug, either prolonging the effects or causing unpredictable fluctuations in symptom relief and side effects.

If someone is considering or curious about taking Vyvanse and Adderall together, it’s essential to consult with a medical professional. It’s never advisable to combine medications without professional guidance. While the allure of amplified benefits might be tempting, the risks associated with stacking these drugs are significant and should be approached with caution.


Dosage: How much Adderall and Vyvanse should you take?

Dosage of Vyvanse (Vyvanse) and Adderall (Adderall) together is not recommended. While they work in different ways to treat ADHD, they do have some similarities. Both add-on medications have similar side effects, such as dry mouth, headache, weight loss, and insomnia. But when taken together, these medications may cause additive effects, such as high blood pressure and a rapid heartbeat. To avoid these undesirable side effects, make sure to consult with your healthcare professional before starting any new treatment plan.

Dosage of Vyvanse is typically higher than that of Adderall, since it is a stimulant. It can increase blood pressure and heart rate, putting you at risk for a heart attack, stroke, or alcohol poisoning. Additionally, both medications have sedative properties. Because they are different, people taking them together could accidentally overdose on one or the other. This could lead to severe symptoms, including chest pains and aggression.

Adderall or Vyvanse

It is important to note that VYVANSE may cause cardiac problems. It has been linked to sudden death in adults and is potentially fatal in children. It can also increase heart rate and blood pressure, so HCPs should monitor patients closely and adjust their dosages accordingly. Do not take VYVANSE more than 50 mg once daily, and consult with your doctor if you experience any of these side effects.

When to take these drugs together, it is important to follow the directions on the packaging. The immediate release version of Adderall lasts for about four to six hours. The extended-release version, however, lasts about 10 to 13 hours, while Vyvanse lasts between ten and fourteen hours. Although the side effects are similar in both products, Vyvanse may be safer and less harmful for the body.


Vyvanse & Adderall Drug Interactions

Taking drugs such as Vyvanse can increase your blood pressure and cause dangerous side effects. You should consult a physician before taking MAOIs. Monoamine oxidase inhibitors include phenelzine, Procarbazine, and isocarboxazid. These medications increase levels of norepinephrine in the brain, which enhances mood and concentration. Although these drugs are rare in treating ADHD, they can help you if other medications have failed.

While it is safe to take Adderall alone, it can also interact with MAO inhibitors and other drugs that act on the same neurotransmitters. Taking Adderall with an MAO inhibitor can cause severe side effects, such as numbness, seizures, or increased heart rate. Additionally, it is important to consult with your doctor before taking any MAO inhibitors, such as phenelzine and Vyvanse, as they can increase the absorption of Adderall.

Using Vyvanse and Adderall simultaneously is a risky proposition. They both have serious potential for abuse. Both can increase the risk of heart problems, including heart attack, stroke, and even death. Therefore, it’s important to have a regular heart checkup before taking either one. In addition, people who take both should disclose any other medical conditions that may complicate their use of either drug.

While Vyvanse is often marketed as a “smoother” than Adderall, it’s possible to overdose with these drugs. The extended-release version of Adderall lasts 10-12 hours, while Vyvanse can last 14 hours. Both drugs can result in priapism, an over-the-counter drug that causes a penile erection lasting more than four hours.


Other drugs to avoid mixing with Vyvanse or Adderall

Other Drugs to Avoid Mixing with Vyvanse or Adderall

Both Vyvanse and Adderall are powerful stimulant medications primarily prescribed to treat ADHD. Due to their potent effects on the central nervous system and cardiovascular system, mixing them with other drugs can be risky. Let’s explore some medications and substances that should generally be avoided when taking Vyvanse or Adderall:

  1. Monoamine Oxidase Inhibitors (MAOIs): These are a class of antidepressants that can cause dangerous interactions when mixed with stimulants. Combining them can lead to a hypertensive crisis, a potentially life-threatening condition where blood pressure rises rapidly.
  2. Blood Pressure Medications: Since Vyvanse and Adderall can increase blood pressure and heart rate, combining them with antihypertensive drugs can cause unpredictable blood pressure fluctuations.
  3. Antacids: Over-the-counter antacids can increase the absorption of amphetamines in the intestines. This can lead to increased blood levels of drugs like Adderall, intensifying both therapeutic effects and side effects.
  4. Certain Antidepressants: Some SSRIs (like Prozac) or SNRIs might increase the levels of amphetamines in the body, increasing the risk of side effects.
  5. Alcohol: Mixing alcohol with Vyvanse or Adderall can mask the depressant effects of alcohol, leading to overconsumption. It can also increase the risk of cardiovascular events.
  6. Other Stimulants: This includes caffeine, pseudoephedrine (found in many cold medications), and illicit stimulants like cocaine or methamphetamine. Combining these can amplify side effects and place strain on the heart.
  7. Sedatives and Benzodiazepines: Some might use sedatives to counteract the stimulating effects of Vyvanse or Adderall. This is risky as it can lead to a cycle of uppers and downers, increasing the potential for addiction and other adverse effects.

In essence, Vyvanse and Adderall have significant interactions with various medications and substances. If someone is prescribed either of these drugs, it’s crucial to disclose all medications, supplements, and substances they’re consuming to their healthcare provider. This will help avoid potential dangerous drug interactions and ensure safe, effective treatment.


How To Get The Most Out Of Adderall or Vyvanse

Maximizing the benefits of medications like Adderall or Vyvanse while ensuring safety is of paramount importance. Beyond taking the drug as prescribed, there are strategies to potentiate its effects and improve cognitive function. Recently, nootropics have gained attention for their potential to complement ADHD medications.

  1. Nootropics: Nootropics, commonly referred to as ‘smart drugs’, are supplements that boost cognitive performance. When combined with stimulant medications, they can offer complementary benefits.
    • Vyvamind: This nootropic is believed to support cognitive function and mental clarity. When combined with Vyvanse or Adderall, it may potentially enhance focus and concentration without increasing the risk of overstimulation.
    • Nooceptin: Similar to Vyvamind, Nooceptin is designed to optimize brain function. Its unique blend of ingredients may work synergistically with ADHD medications, promoting improved memory retention and mental endurance.
  2. Consistent Schedule: Taking your medication at the same time daily helps maintain stable levels in the bloodstream, ensuring consistent effects.
  3. Balanced Diet: A nutritious diet supports overall brain health. Consuming a balance of proteins, complex carbs, and healthy fats can ensure optimal neurotransmitter function, complementing the actions of ADHD medications.
  4. Adequate Sleep: Sleep is crucial for cognitive function. Ensuring a good night’s sleep can make ADHD medications more effective, as a well-rested brain is more receptive to their benefits.
  5. Avoid Caffeine Overconsumption: While a moderate amount of caffeine might be okay, overdoing it can lead to overstimulation, especially when on stimulant medications.
  6. Stay Hydrated: Stimulants can be dehydrating. Drinking adequate water supports brain function and can enhance the medication’s effectiveness.

It’s important to note that while nootropics like Vyvamind and Nooceptin show promise in supporting cognitive enhancement, individual reactions can vary. Before combining them with ADHD medications, it’s essential to consult with a healthcare professional to ensure safe and effective use.

 

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About the Author P. Tardner


Paul Tardner is the Head Writer at IJEST.org. Paul is a former academic and research scientist. He now dedicates his time to his own research into nootropics, with a particular focus on cognitive enhancement in old age. You can learn more about Paul from his profile page.

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