Sulbutiamine and benfotiamine are both synthetic derivatives of thiamine, otherwise known as vitamin B1. As enhanced forms of a vital nutrient, they possess unique characteristics that make them of particular interest to those in the field of nootropics - supplements designed to optimize cognitive function. These two compounds, while having a common origin, have taken diverse paths in their scientific development, leading to distinct potential benefits, usage, and profiles within the world of cognitive enhancement.

This article aims to shed light on these two intriguing compounds. We will delve into an in-depth comparison of sulbutiamine and benfotiamine, basing our examination on various factors. These include their nootropic effects – the ways in which they may enhance cognitive performance – potential side effects, and their suitability for use in conjunction with other nootropics. We'll explore the underlying mechanisms that contribute to their unique attributes, and discuss scientific studies backing their efficacy. Our aim is to provide you with a comprehensive understanding that will enable you to make informed decisions about whether these supplements might be beneficial in your personal pursuit of cognitive optimization.

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Nootropic Effects


Sulbutiamine is a synthetic derivative of thiamine, created to increase the bioavailability and lipophilicity of thiamine in the brain. It is known for its potential cognitive-enhancing effects, including:

  • Improving attention and focus (Bizot et al., 2005)

  • Reducing fatigue and increasing energy levels (Balzamo & Vuillon-Cacciuttolo, 1985)

  • Enhancing memory and learning (Trovero et al., 2000)

  • Modulating dopamine transmission by increasing dopamine D1 receptor density in the prefrontal cortex (Tiev et al., 1999)

Sulbutiamine nootropic


Benfotiamine is another synthetic thiamine derivative, primarily known for its potential benefits in managing diabetic neuropathy and other peripheral neuropathies (Stracke et al., 2001). However, its nootropic effects are less well-studied than those of sulbutiamine. Some potential cognitive benefits of benfotiamine include:

  • Reducing inflammation and oxidative stress in the brain, which could potentially benefit cognitive function (Pan et al., 2010)
  • Protecting against memory deficits in animal models of Alzheimer's disease (Wang et al., 2016)
Benfotiamine nootropic

Sulbutiamine and benfotiamine, both synthetic derivatives of thiamine, offer a variety of nootropic benefits. Sulbutiamine is recognized for improving attention, reducing fatigue, enhancing memory, and modulating dopamine transmission. On the other hand, benfotiamine is more widely known for managing diabetic and peripheral neuropathies, with its nootropic potentials less explored. 

Nevertheless, its benefits may include reducing inflammation, oxidative stress in the brain, and protecting against memory deficits in Alzheimer's disease models, indicating potential for cognitive enhancement. Despite originating from the same vitamin, their unique nootropic profiles offer different advantages.

Side Effects


Sulbutiamine is generally considered safe and well-tolerated, with few reported side effects. However, some individuals may experience:

  • Mild gastrointestinal issues

  • Skin rash or irritation

  • Insomnia or sleep disturbances

  • Irritability or anxiety


Similarly, benfotiamine is also considered safe and well-tolerated, with few reported side effects. Potential side effects of benfotiamine may include:

  • Mild gastrointestinal issues

  • Allergic skin reactions (rare)

It is essential to consult a healthcare professional before starting any new supplement regimen, especially if you have pre-existing health conditions or are taking medications.

Is Sulbutiamine or benfotiamine safer for long-term use?

Sulbutiamine and benfotiamine are both synthetic thiamine derivatives with unique nootropic properties. When comparing the long-term safety of these compounds, both are generally considered well-tolerated with few reported side effects. However, sulbutiamine is more widely studied for its cognitive-enhancing effects, while benfotiamine is primarily known for managing diabetic neuropathy. 

As with any supplement, individual responses may vary, and consulting a healthcare professional is essential before incorporating either sulbutiamine or benfotiamine into a long-term nootropic regimen. Overall, both compounds appear to have a favorable safety profile for long-term use.

Suitability for Use with Other Nootropics

Both sulbutiamine and benfotiamine can be combined with other nootropics for enhanced cognitive benefits. However, their unique properties and effects may make them more suitable for different nootropic stacks.


Sulbutiamine's potential to improve attention, focus, and dopamine modulation makes it a suitable candidate for stacking with other nootropics targeting cognitive performance, particularly in the context of ADHD or cognitive decline. Some nootropics that may be combined with sulbutiamine include:

  • Citicoline: May synergistically improve focus and cognitivefunction in individuals with ADHD.

  • Caffeine: Can provide a more significant boost in attention and focus when combined with sulbutiamine. 

  • L-Tyrosine: May help address underlying neurotransmitter imbalances in individuals with ADHD when stacked with sulbutiamine.


Given its potential benefits in reducing inflammation and oxidative stress, benfotiamine may be more suitable for stacking with nootropics targeting brain health and neuroprotection. Some nootropics that could be combined with benfotiamine include:

  • Alpha-GPC: May support overall brain health and cognitive function.

  • Bacopa Monnieri: A natural adaptogen that may help improve memory and protect against cognitive decline.

  • Curcumin: A powerful antioxidant that may help reduce inflammation and oxidative stress in the brain.


Sulbutiamine and benfotiamine are both synthetic derivatives of thiamine with unique properties and potential benefits as nootropics. While sulbutiamine is more well-known for its cognitive-enhancing effects, such as improving attention, focus, and memory, benfotiamine has been shown to reduce inflammation and oxidative stress in the brain, potentially benefiting cognitive function.

Both compounds are generally considered safe and well-tolerated, with few reported side effects. However, it is essential to consult a healthcare professional before starting any new supplement regimen, especially if you have pre-existing health conditions or are taking medications.

When considering their suitability for use with other nootropics, sulbutiamine's potential to improve attention, focus, and dopamine modulation may make it more appropriate for stacking with cognitive-enhancing nootropics like citicoline, caffeine, or L-Tyrosine. On the other hand, benfotiamine's potential benefits in reducing inflammation and oxidative stress may make it more suitable for stacking with neuroprotective nootropics like alpha-GPC, Bacopa Monnieri, or curcumin.


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  • Balzamo, E., & Vuillon-Cacciuttolo, G. (1985). Effects of thiamine and its phosphate esters on the sleep-wake cycle in the rat. Psychopharmacology, 85(2), 141-145.

  • Bizot, J. C., Herpin, A., Pothion, S., Pirot, S., Trovero, F., & Ollat, H. (2005). Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29(6), 928-935.

  • Pan, X., Gong, N., Zhao, J., Yu, Z., Gu, F., Chen, J., ... & Zhu, Y. (2010). Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. Brain, 133(5), 1342-1351.

  • [Stracke, H., Gaus, W., Achenbach, U., Federlin, K., & Bretzel, R. G. (2001). Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Experimental and Clinical Endocrinology

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About the Author P. Tardner

Paul Tardner is the Head Writer at Paul is a former academic and research scientist. He now dedicates his time to his own research into nootropics, with a particular focus on cognitive enhancement in old age. You can learn more about Paul from his profile page.