Armodafinil Review | What You MUST Know

Armodafinil is a drug that works to increase wakefulness, combat fatigue and improve cognitive function. This article includes the pros and cons of using this compound with unique insight into its effects on your brain.

Armodafinil is a medication that has been used to help people with sleep disorders and narcolepsy. It is also being used for other purposes. Armodafinil can be taken as a pill or an injection. The drug was first synthesized in France in the year 1961, but was not approved until 1997.

Armodafinil Review | What You MUST Know

Are you looking for a comprehensive Armodafinil review?

You’ve come to the correct spot. In the field of nootropics, armodafinil is a relative newcomer. It was created approximately two decades after Modafinil, yet it has a molecular structure and action that are quite comparable.

What exactly is Armodafinil? What exactly does it do?

And, maybe most importantly, does it function?

We’ll go through the research on this medication and smart medicine in the sections below. To provide you with the information you need to make an educated choice about whether or not to add this strong nootropic to your optimization stack.

 

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Modafinil.com’s material is provided only for educational and informative reasons. We do not provide legal counsel. We also don’t provide medical advice, diagnosis, or treatment. Please with your doctor before using Modafinil or other nootropics. Our entire Disclaimer and Terms of Use apply to your use of Modafinil.com.

 

Overview

Armodafinil is a prescription medicine that helps people stay awake. It is often recommended to persons who are very sleepy as a consequence of a sleep problem. While Armodafinil does not cure the problems, it does assist its users in being awake and functioning during the day.

Doctors prescribe armodafinil for both on-label and off-label reasons. On-label applications include [2]:

  • Narcolepsy
  • Obstructive sleep apnea (OSA) is a kind of sleep apn
  • Workplace disruption

Doctors may prescribe it for a variety of off-label reasons, including:

  • ADHD
  • Syndrome of chronic tiredness
  • Depressive illness (major depression)

It has been repeatedly shown to be beneficial for the stated purpose of keeping people awake and providing energy [3, 4, 5].

 

 

 

Benefits

Because there has been so much study on these effects, we know that Modafinil has a slew of them. Unfortunately, there isn’t as much study on the cognitive effects of Armodafinil as there is on Modafinil.

Part of the reason for this is because Armodafinil has only been around for roughly 20 years, so there hasn’t been as much time to do high-quality study on it.

Nonetheless, a few studies have shown that Armodafinil provides comparable cognitive advantages as Modafinil. Armodafinil has been shown to have the following nootropic effects in studies:

  • Memory. Participants using Armodafinil had considerably improved memory quality and speed than those receiving a placebo in randomized control studies [5, 6].
  • Tiredness and arousal. Armodafinil improves alertness and reduces tiredness in both healthy people and those with different health issues, according to many studies [5, 6, 7].
  • Focus and alertness Armodafinil has been shown in many trials to promote alertness and attentional concentration [5, 6]. All of the claims of mad productivity originate here.
  • Mood. Armodafinil, like Modafinil, has been shown to boost mood and lessen depression symptoms in several studies [8, 9]. That’s why it’s utilized as a supplemental treatment for depression sufferers.

Armodafinil’s entire spectrum of effects has yet to be determined since there hasn’t been as much study done on it. Researchers believe its effects are quite comparable to those of its relative, Modafinil. Although there haven’t been any research on Armodafinil yet, the following Modafinil cognitive advantages may also apply to Armodafinil:

  • [10] Better spatial planning
  • [10] Improved visual pattern recognition
  • [10] Faster reaction times
  • Improved plan development [10]
  • Better long-term planning [11]
  • Improved decision-making capabilities [11]
  • Visual processing [12] is improved.
  • Increased work motivation [13]

Again, research has only proven such effects in Modafinil so far; testing in Armodafinil is still in the works. Nonetheless, our personal experience reveals that Armodafinil and Modafinil have very comparable cognitive-enhancing effects.

Researchers think that these two medications are comparable and function in similar ways in general [1], thus it seems logical to anticipate them to have similar cognitive effects.

 

Consequences

Just like any medication, some users report Consequences from Armodafinil. However, they are typically relatively uncommon and are usually not severe. The most common Armodafinil Consequences, along with their estimated prevalence rates, are [14]:

  • Migraines (17 percent )
  • Nausea (7 percent )
  • Disorientation (5 percent )
  • Sleeplessness (5 percent )
  • Anxiety (4 percent )
  • Constipation (4 percent )
  • Mouth Dryness (4 percent )
  • Depressed mood (2 percent )
  • Fatigue (2 percent )
  • Heart palpitations (2 percent )

In addition to being generally uncommon and of mild severity, the majority of these Consequences were dose-dependent. That means they were more likely to occur at larger doses.

In our experience, some of these Consequences are avoidable. We’ve found the following are effective strategies to reduce the likelihood of experiencing Armodafinil Consequences:

  • Begin with a little dosage. You’ll be able to observe how it impacts you this way. Start with 50 mg. For additional information on how to pick a suitable dose, see our Armodafinil dosage guide.
  • Don’t dose higher than 150 mg. While you can find Armodafinil tablets in 200 mg and 250 mg doses, we don’t recommend them. Larger doses don’t give any added benefit and they make you more likely to experience Consequences.
  • It is best taken first thing This morning. If you’re not cautious, armodafinil may cause insomnia. To avoid this, take it as soon as you get up This morning, preferably before 10:00 a.m.
  • It should be taken with meals. We’ve found that having a full meal before taking Armodafinil may assist with nausea and stomach troubles. Because armodafinil might suppress appetite, it’s critical to remember to eat.
  • Get some water. One of the greatest methods to prevent dehydration and headaches is to stay hydrated.

 

 

Safety of Armodafinil

There are some Consequences, but is Armodafinil considered safe?

Yes. Armodafinil is well accepted by practically everyone and is deemed completely safe by researchers [8, 9, 15]. However, there are several things to keep in mind if you want to take Armodafinil safely.

Armodafinil Dosage Recommendation

The following is the suggested dosage for people with narcolepsy or sleep apnea:

  • 150mg to 250mg
  • Taken as a single dosage orally
  • This morning

For people seeking nootropic advantages, we recommend the following Armodafinil dosage:

  • 150mg
  • Taken as a single dosage orally
  • This morning (before 10:00 am)
  • With or shortly after a substantial meal

Overdose

Armodafinil’s overdose potential has received limited direct investigation. Instead, scientists believe it has a comparable safety and overdose profile as its relative Modafinil [16].

The information on Modafinil overdose is very clear. While overdoses (taking more than the prescribed dose) increases the likelihood of experiencing Consequences, there is virtually no danger of permanent damage or death.

Individuals have consumed up to 8 grams of the substance—more than 80 times the permissible dose—and remained in stable condition, according to case reports.

Based on extensive studies on Modafinil overdose and the similarities between Armodafinil and Modafinil, experts are sure that an overdose of Armodafinil is not fatal [17].

Interactions and Contraindications with Armodafinil

When Armodafinil alters the efficacy or potency of another medicine, this is known as an interaction. If you’re also using [14], it’s best not to take Armodafinil to prevent interactions.

  • Contraceptive pills (steroidal)
  • Cyclosporine
  • Midazolam
  • Triazolam
  • Phenytoin
  • Diazepam
  • Propranolol
  • Omeprazole
  • Clomipramine
  • Warfarin

Populations at Risk

Because armodafinil is new, it hasn’t been well tested in all groups. If you belong to one of the following groups, you should take extra precautions:

  • Patients with significant liver disease should talk to their doctor about lowering their Armodafinil dose [14].
  • Geriatric populations: Because older people’s capacity to absorb Armodafinil may be impaired, physicians might consider lowering their dose [14].
  • Armodafinil may damage a baby in pregnant women, according to animal studies. As a result, do not use Armodafinil while pregnant [14].
  • Children: No safety data on children has been established. This group should not be exposed to it [14].

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Legality

Armodafinil is a Schedule IV restricted drug in the United States, according to the Controlled Substances Act [18]. That it has been recognized to have acknowledged medicinal applications and a minimal risk of misuse. The FDA authorized it for prescription usage in the United States in 2007.

Armodafinil is also only accessible via prescription in most other countries. Only a few nations, like Mexico and India, have it accessible over-the-counter.

This means that the only 100% legal way to get Armodafinil in the majority of countries is to get a prescription from your doctor. To be eligible for a prescription, you will likely need to have a diagnosis of Narcolepsy, Obstructive sleep apnea (OSA) is a kind of sleep apn, or shift work disorder.

Professional sports are still another major legal aspect. Most athletic leagues and organizations, including the WADA and the USADA, have banned armodafinil as a performance-enhancing substance [19].

 

Pharmacology

So, what exactly is Armodafinil comprised of? What effect does it have on the body? This section is for chemistry buffs: it describes what Armodafinil is and how it works. 

Chemical Composition

Armodafinil and Modafinil were both designed for the same purpose by the same company, which may help explain why the Chemical Composition of Armodafinil vs. Modafinil is not very different.

2-[(R)-(diphenylmethyl)sulfinyl]acetamide is the chemical name for Armodafinil. C15H15NO2S [14] is its chemical formula.

Modafinil features a two enantiomer structure—it has both the “R-” and “S+” enantiomers present. The Chemical Composition of Armodafinil is basically just one half that of Modafinil—it has just the “R-” enantiomer [14]

This indicates that a lesser dosage of Armodafinil is usually required to achieve equivalent effects to Modafinil [14].

Action Mechanisms

Armodafinil, like Modafinil, has a complex mechanism of action [20].

Scientists believe it has an impact in numerous ways, some of which are indirect. The dopamine pathways are one method. Armodafinil binds to dopamine receptors and blocks reuptake, resulting in higher dopamine levels at synapses. Armodafinil’s mood-altering impact is most likely due to dopamine.

Other Armodafinil effects are unknown, however it seems to boost the availability of a number of neurotransmitters involved in wakefulness [20]. Orexin, norepinephrine, histamine, and serotonin are among them.

Armodafinil also has the following pharmacological features [21]:

  • A half-life of 11.5 to 15.5 hours for elimination
  • It takes around 2.5 hours for it to reach peak concentration in your bloodstream—longer if taken with meals.
  • Armodafinil seems to stay in the body longer than Modafinil.
  • Armodafinil is largely processed by the liver, which includes CYP3A4 pathways.
  • Armodafinil is mostly eliminated via the urine.

 

 

2022 Guide: Where to Buy Armodafinil Online

Armodafinil is available in generic form from a variety of online pharmacies.

According to one investigation, there were more than 55 websites offering Armodafinil and Modafinil [22]. You’re inundated with options. However, although many of these sites are useful and trustworthy, some are not. You must be cautious in selecting merchants who will not defraud you.

We’ve identified a collection of merchants you can trust to provide a high-quality product at a reasonable price that will really reach you after a lot of trial and error. These companies are recommended because they:

  • Have fantastic deals and pricing
  • Have a delivery guarantee
  • Have a variety of payment choices
  • Provide excellent client service.

We suggest ordering from them, particularly if this is your first time ordering Armodafinil online.

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Best Armodafinil Generic

You’ve made the decision to stop taking Armodafinil. Now all you have to do is decide which type you want. For Armodafinil beginners, this may be a little perplexing, so let’s break it down for you.

  • Armodafinil is sold under the brand name Nuvigil. We do not advocate buying Nuvigil since it is much more costly and only available in pharmacies in the United States and Europe. To receive it, you’ll need a doctor’s prescription.
  • Waklert — “Waklert” is Armodafinil’s equivalent of “Modalert.” This is the most powerful and long-lasting type of generic Armodafinil available. Sun Pharmaceuticals manufactures it, and it generally delivers 8 to 10 hours of improved cognition without interfering with your nocturnal sleep.
  • The “Modvigil” form of Armodafinil is Artvigil. It’s not as strong as Waklert and usually doesn’t last as long. HAB Pharmaceuticals manufactures it, and it’s great for anyone searching for Armodafinil at a reduced cost.

Waklert, in our opinion, is the greatest kind of generic Armodafinil available online. Anyone interested in trying out this nootropic should do so.

Artvigil, on the other hand, is a bit less expensive if money is limited. When seeking for an Armodafinil alternative, Artvigil will save you some money while still being a good choice.

 

Country-By-Country

The acquisition and usage of Armodafinil are governed by various laws in each nation. This will evaluate whether it is suitable for you.

Because we understand that getting Armodafinil or other nootropics in different countries might be perplexing, we’ve prepared a library of articles with nootropic country guides to provide you all the information you need. Check your country’s website for more precise information on how to get Armodafinil.

Here’s a short rundown of Armodafinil’s availability for your convenience:

  • Armodafinil is a schedule F medication in Canada. It can only be obtained through prescription.
  • Armodafinil is only accessible via prescription in most European nations.
  • Armodafinil is a Schedule 4 substance in Australia, according to the Standard for the Uniform Scheduling of Medicines and Poisons [23]. It’s only accessible with a doctor’s prescription.
  • Armodafinil is sold over-the-counter in India.
  • Armodafinil is strictly regulated in China and is not accessible for medical purposes. Even with a prescription, it’s tough to get.
  • Armodafinil is only available on prescription in South Africa.

 

History

Armodafinil’s history is intertwined with that of Modafinil to a large degree.

Modafinil was developed and tested in France throughout the 1970s, 1980s, and 1990s. It finally became available for use in the USA in 1998 from Cephalon under the brand name Provigil. It became one of the most common treatments for excessive sleepiness that results from Narcolepsy, Obstructive sleep apnea (OSA) is a kind of sleep apn, and shiftwork sleep disorder.

Companies that produce a new prescription pharmaceutical often hold exclusive manufacturing and distribution rights for about two decades. However, Cephalon’s Modafinil patent was slated to expire in the 2000s.

Cephalon attempted to produce a new medicine that had comparable effects to Modafinil in order to compensate for the possible loss of profit margins that would follow from expanded availability to generic Modafinil. Through this research and development, Armodafinil was created.

Armodafinil was developed in France and authorized in the United States in 2007 under the brand name Nuvigil [24]. In 2016, the FDA in the United States authorized the first generic Armodafinil for sale [25].

 

FAQ

We wanted to address a few more questions for you before ending off our comprehensive Armodafinil review.

Including fascinating items like as…

Is there a “high” from Armodafinil?

Sort of. There is an Armodafinil high, just as there is a Modafinil high, but it’s probably not the same as the “high” you’re accustomed to. It’s not the same as marijuana, cocaine, or LSD, for example. It’s also not like being “buzzed.”

You can, however, feel Armodafinil functioning. The sensation is one of strong concentration, clear thinking, and a mood lift. Some persons even report feeling euphoric as a consequence of the drug’s influence on the dopamine circuits [13]. With an Armodafinil high, however, you always have control of yourself.

How long does Armodafinil keep you awake?

Armodafinil has a half-life of 13.5 hours [21], thus it stays in your system for a long time. We’ve found that it gives you roughly 8 to 10 decent work hours, which is little less than Modafinil.

Is it possible to sleep on Armodafinil?

No. Armodafinil is a sedative with the sole objective of keeping you awake. And it does so admirably. If you take armodafinil too close to bedtime, it will undoubtedly interfere with your sleep.

Armodafinil is best taken before 10:00 a.m., in our experience. That way, you enjoy the excellent benefits all day long while still being able to fall asleep when it’s time to sleep.

Is Armodafinil detectable in a drug test?

It is dependent on the kind of drug test utilized.

Armodafinil is not tested for by most drug testing panels. You will not test positive for other substances like amphetamines if you take Armodafinil [26].

Armodafinil, on the other hand, may be detected in your blood and urine, and it can linger in your system for up to three days. It may be found in hair samples for considerably longer [27].

Armodafinil may show up on a drug test if you are in a situation where they can screen for it, such as a professional sports event.

 

 

Armodafinil is really amazing.

Most individuals who are acquainted with nootropics are familiar with Modafinil, yet many still have questions:

What is Armodafinil, exactly?

Although Armodafinil is not as well-known as Modafinil, it can certainly stand on its own. It works as a wakefulness aid as well as a nootropic, according to study.

Armodafinil might make all the difference in situations when cognitive function is critical. It not only gives you limitless energy for hours, but it also helps you concentrate and remember things better. According to studies on Modafinil, Armodafinil is expected to improve a variety of cognitive processes such as planning and decision-making.

Armodafinil is a very intelligent medicine. It will help you concentrate and improve your intellect. 

Armodafinil may be a good alternative for you if you want to boost your productivity and get more done.

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References

    1. Chapman, J. L., Vakulin, A., Hedner, J., Yee, B. J., & Marshall, N. S. (2016). Modafinil/armodafinil in obstructive sleep apnoea: a systematic review and meta-analysis. European Respiratory Journal, 47(5), 1420-1428.
    2. FDA (n.d.). Highlights of prescription information for armodafinil. https://www.accessdata.fda.gov/drugsatfda docs/label/2017/021875s023lbl.pdf
    3. Hirshkowitz, M., Black, J. E., Wesnes, K., Niebler, G., Arora, S., & Roth, T. (2007). Adjunct armodafinil improves wakefulness and memory in Obstructive sleep apnea (OSA) is a kind of sleep apn/hypopnea syndrome. Respiratory Medicine, 101(3), 616-627.
    4. Nishino, S., & Okuro, M. (2008). Armodafinil for excessive daytime sleepiness. Drugs Today, 44(6), 395-414.
    5. Harsh, J. R., Hayduk, R., Rosenberg, R., Wesnes, K. A., Walsh, J. K., Arora, S., … & Roth, T. (2006). The efficacy and safety of armodafinil as treatment for adults with excessive sleepiness associated with Narcolepsy. Current Medical Research and Opinion, 22(4), 761-774.
    6. Czeisler, C. A., Walsh, J. K., Wesnes, K. A., Roth, T., & Arora, S. (2009, November). Armodafinil for treatment of excessive sleepiness associated with shift work disorder: A randomized controlled study. Mayo Clinic Proceedings 84(11), 958-972
    7. Roth, T., Rippon, G. A., & Arora, S. (2008). Armodafinil improves wakefulness and long-term episodic memory in nCPAP-adherent patients with excessive sleepiness associated with Obstructive sleep apnea (OSA) is a kind of sleep apn. Sleep and Breathing, 12(1), 53-62.
    8. Calabrese, J. R., Ketter, T. A., Youakim, J. M., Tiller, J. M., Yang, R., & Frye, M. A. (2010). Adjunctive armodafinil for major depressive episodes associated with bipolar I disorder: a randomized, multicenter, double-blind, placebo-controlled, proof-of-concept study. The Journal of Clinical Psychiatry, 71(10), 1363-1370.
    9. Calabrese, J. R., Frye, M. A., Yang, R., & Ketter, T. A. (2014). Efficacy and safety of adjunctive armodafinil in adults with major depressive episodes associated with bipolar I disorder: a randomized, double-blind, placebo-controlled, multicenter trial. The Journal of clinical psychiatry, 75(10), 1054-1061.
    10. Turner, D. C., Robbins, T. W., Clark, L., Aron, A. R., Dowson, J., & Sahakian, B. J. (2003). Cognitive enhancing effects of modafinil in healthy volunteers. PsychoPharmacology, 165(3), 260-269.
    11. Müller, U., Rowe, J. B., Rittman, T., Lewis, C., Robbins, T. W., & Sahakian, B. J. (2013). Effects of modafinil on non-verbal cognition, task enjoyment and creative thinking in healthy volunteers. NeuroPharmacology, 64, 490-495.
    12. Lees, J., Michalopoulou, P. G., Lewis, S. W., Preston, S., Bamford, C., Collier, T., … & Kapur, S. (2017). Modafinil and cognitive enhancement in schizophrenia and healthy volunteers: The effects of test battery in a randomised controlled trial. Psychological Medicine, 47(13), 2358-2368.
    13. Volkow, N. D., Fowler, J. S., Logan, J., Alexoff, D., Zhu, W., Telang, F., … & Hubbard, B. (2009). Effects of modafinil on dopamine and dopamine transporters in the male human brain: Clinical implications. JAMA, 301(11), 1148-1154.
    14. www.drugs.com (2019). https://www.drugs.com/pro/armodafinil.html Armodafinil
    15. Chapman, J. L., Vakulin, A., Hedner, J., Yee, B. J., & Marshall, N. S. (2016). Modafinil/armodafinil in obstructive sleep apnoea: a systematic review and meta-analysis. European Respiratory Journal, 47(5), 1420-1428.
    16. Hirai, N., & Nishino, S. (2011). Recent advances in the treatment of Narcolepsy. Current Treatment Options in Neurology, 13(5), 437.
    17. http://www.drugsandme.com/ (n.d.). Armodafinil, Adrafinil, Daffy, Provigil, Modalert, Modvigil, Artvigil, Waklert are all examples of modafinil. https://www.drugsand.me/en/drugs/modafinil/
    18. D. A. Lankford (2008). Armodafinil is a novel therapy for drowsiness. 565-573 in Expert Opinion on Investigational Drugs.
    19. American Anti-Doping Agency (2018). Prohibited and allowed drugs on a wallet card. https://www.usada.org/wp-content/uploads/wallet-card.pdf
    20. Gerrard, P., & Malcolm, R. (2007). Mechanisms of modafinil: a review of current research. Neuropsychiatric Disease and Treatment, 3(3), 349.
    21. Darwish, M., Kirby, M., Hellriegel, E. T., & Robertson, P. (2009). Armodafinil and modafinil have substantially different pharmacokinetic profiles despite having the same terminal half-lives. Clinical Drug Investigation, 29(9), 613-623.
    22. Hockenhull, J., Wood, D. M., & Dargan, P. I. (2020). The Availability of Modafinil and Methylphenidate Purchased from the Internet in the United Kingdom Without a Prescription. Substance Use & Misuse, 55(1), 56-65.
    23. Australia’s government (2018). March 2018 Poison Standards https://www.legislation.gov.au/Details/F2018L00168/Html/Text# Toc500931888
    24. FDA (n.d.). NDA 21-875/NUVIGILTM (armodafinil) Tablets FDA Approved Labeling Text https://corpina.com/wp-content/uploads/2014/01/Armodafinil FDA Approval-.pdf
    25. MyLan (2016). Mylan has released the first generic version of Nuvigil® tablets. https://newsroom.mylan.com/2016-06-01-Mylan-Launches-First-Generic-of-Nuvigil-Tablets
    26. http://www.singlecare.com/ (2020). Differences, similarities, and which is best for you between armodafinil and modafinil. Will percent 20armodafinil% 20show percent 20on% 20a,positives% 20for% 20amphetamine% 20are% 20rare. https://www.singlecare.com/blog/armodafinil-vs-modafinil/#::text=Will percent 20armodafinil% 20show percent 20on% 20a,positives% 20for% 20amphe
    27. The Rehabilitation Center (2020). How Long Does Armodafinil Last In The Body? https://www.therecoveryvillage.com/armodafinil-addiction/how-long-stay-in-system

 

 

Armodafinil is a medication that has been approved to treat narcolepsy and shift work sleep disorder. It is also used recreationally for its stimulant-like effects. Armodafinil not working? Here are some possible reasons why it might be failing. Reference: armodafinil not working.

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About P. Tardner

Paul Tardner is the Lead Author at IJEST.org. Paul is a former academic and research scientists. He now dedicates his time to his own research into natural biohacking, with a particular focus on cognitive enhancement.

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