If you’ve spent any time researching nootropics, then you will have already read a lot about the racetams. Of all the different subclasses of nootropic “smart drugs” out there, the racetams are easily the most well-known and widely-used. The are really the archetypal brain supplement; Piracetam was the first nootropic to be discovered and the compound sort of embodies the definition of the word.

Racetams are a class of anticonvulsant and nootropic smart drugs. They are typically employed to improve general brain health as well as treating patients suffering from anxiety or epileptic seizures.

They are used extensively to boost memory and cognition by enhancing mood, focus and learning, as well as enhancing the visual attention and feeling of being aware.

In the racetam list below we have selected the top ones to think about in terms of efficiency, unique benefits as well as security. So keep reading to learn more about the best racetams, the dosage that is required to help you, as well as the general overview for each of the nootropics.

What are Racetams?

Racetams are a group of drugs with the common characteristic of possessing an organic compound known as 2-pyrrolidone nucleus.

They are all made of synthetic material and share similar chemical structures, like hydrogen, nitrogen, and oxygen.

In racetam analysis, they differ in their specific uses, functions, and dosages.

Mechanism of action of racetams involves affecting the receptors of the nervous system. Generally speaking, racetams will work either by increasing activity in the acetylcholine system or the GABA systems within the brain. The effect of this is to increase executive cognitive performance while lowering anxiety.

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Top 7 Best Racetam Nootropics Comparison

The most well-known nootropic in the racetam group is Piracetam. It is the racetam’s first nootropic.

Other racetams were made structurally like Piracetam and include more than twenty derivatives that were used to improve cognitive performance.

The following are generally thought to be the 7 best racetams on the market:

1. Piracetam
2. Aniracetam
3. Oxiracetam
4. Pramiracetam
5. Phenylpiracetam
6. Coluracetam
7. Nefiracetam

Let’s go through these racetams in a little more detail. Below is a brief overview of what each of these top racetams is, how it works, and what the specific benefits are in terms of the effects. We will also talk about the side effects and correct dosages of each racetam.

1. Piracetam

Piracetamnootropic was first discovered in 1964. This nootropic is effective for treating cognitive decline.

Piracetam nootropics increase the fluidity of cell membranes. Studies show that it improves the ability of a person to learn and improves memory retention, but it has less effectiveness than the newer racetams.

The racetams that aren’t similarly organized in comparison to Piracetam include Nefiracetam, Fasoracetam, Coluracetam and Noopept.

Noopept is the closest similar nootropic because of its efficacy. The mechanism of the action that is the basis of Noopept nootropics is similar as that of Piracetamthat alters the synapses in the brain.

The only distinction is that Noopept’s psychostimulatory effect is less obvious.

Benefits and Side Effects

Piracetam is an effective cognitive booster that aids in improving memory and learning, focus and creativity, as well as speech fluency, and concentration.

It reduces anxiety and depression for numerous. Another benefit of this drug is its neuroprotective properties which reduce the risk of injuries and toxins harmful for the brain.

Piracetam nootropics also support mitochondria, which create new energy for cells. Piracetam is an untoxic racetam. its minor effects when misused by some sufferers include headaches and agitation, drowsiness and insomnia.

There were instances of short-term, but not serious muscle spasms, diarrhea, fatigue, hyperactivity, dizziness and dysphoria. Memory loss, and anxiety.

Dosage

It is recommended that Piracetam dose for adult users ranges between 1,200 and 4800 mg (three times) daily. It is estimated to have a 5 hour half-life.

It typically requires 2 to 3 weeks of regular use to reap the full benefit. The majority of people advise new users on racetam forums to take an interruption in their usage every 18 months.

2. Aniracetam

Aniracetamwas later developed in the 1970s to assist with treatment of cognitive disorders and to enable more focus and concentration.

Research has shown that Aniracetam nootropics are between 2 and five times more potent when compared to Piracetam.

Research has shown that when Aniracetam is in use, it affects neurons’ AMPA receptors and binds with serotonin, dopamine and acetylcholine receptors.

This means that a person’s mood as well as concentration and well-being improve. Others also said Aniracetam can help people have vivid dreams.

Benefits and Side Effects

Biohackers suggest Aniracetam as a nootropic for those looking to increase their creativity because it improves the efficiency in the right brain.

The distinctive feature of Aniracetam is its ability to act in a way to act as an anxiolytic. This allows many people to reduce stress, anxiety depression, anxiety, and stress.

These nootropics can enhance one’s overall cognitive abilities and increase confidence in social interactions.

Anxiolytic effects of anxiolytic medications can cause excessive relaxation, which can make people find it difficult to complete mental work.

The racetams’ most well-known negative effects include nausea, as many swear it is a horrible taste. There are also insomnia, unease headaches, diarrhea vertigo, rashes that are strong, and anxiety.

Dosage

The dosage of Aniracetam is 500 to 125 mg, at least three times a day. The half-life of the drug is between 2 and 4 hours.

Because it can cause nausea, it is recommended to consume Aniracetam medication along with sweets or yogurt to compensate for the bitter taste. Aniracetam is fat-soluble, and that’s why it is quickly absorbed and processed by the body. Additionally, it can be consumed in the absence of food.

3. Oxiracetam

Oxiracetamnootropics were first discovered in 1977 and have become well-known as a study drug for students. It has been proven to be more effective than Piracetam even in smaller doses. 

Ociracetam specifically increases choline-acetyltransferase (ChAT) that produces more acetylcholine. This means that a person’s memory for long-term and short-term is improved without fog in the brain.

Research has shown Oxiracetam nootropics also increase the binding sites as well as the density of AMPA receptors’ neurotransmitters. This results in a stimulating effect, but without the negative effects of other stimulants.

Benefits and Side Effects

Oxiracetam is ideal for learning and is considered an extremely potent racetam to aid in memory enhancement.

It stops neural decline and enhances other cognitive capabilities like logical thinking, recall and attention as well as concentration.

Oxiracetam can also boost your mood and reduce headaches. Its documented adverse consequences: mild headaches anxiety, high blood pressure nausea, sleep disturbance constipation, hyperexcitability as well as brain fog.

Dosage

Oxiracetam nootropics should be consumed between 400 and 800 mg, two to three times per day.

A lot of users have claimed that their use typically lasts up to 8 hours of half-life.
To eliminate headache-related side effects, the drug’s fans stack Oxiracetam and take it along with Choline.

In this way the neurons in their brains will be able to produce sufficient acetylcholine since Oxiracetam is known to cause the burning of many neurotransmitters.

4. Pramiracetam: The Best Racetam for Memory?

Pramiracetam was discovered in 1978 and created to be 30 times stronger than Piracetam.
This is why Pramiracetam is regarded as the most effective racetam for memory formation and recall. It is a powerful stimulant for long-term memory, learning capabilities as well as recall and concentration.

Pramiracetam has a number of different effects on the brain. It enhances high-affinity choline absorption (HACU) which has significant impacts on the neurotransmitter acetylcholine synthesizing. It increases the flow of blood to the brain, and also reduces the brain chatter that can distract the mind from its activities. But what does this all mean? What are the practical benefits of pramiracetam?

Benefits and Side Effects

Pramiracetam is one of the strongest nootropics that is known to result in laser-sharp focus and laser-sharp concentration. It also prevents memory loss.

A lot of users have also reported that they gain confidence boosts. It improves thought flow and facilitates verbal communication.

It is also the preferred medication for students who are engaged in focus-focused and logical activities like numerical calculations, as well as lengthy and intensive study sessions. A few have reported that following having taken more than the recommended dosage, they’ve experienced headaches dizziness, moodiness nausea, insomnia, lack of appetite and a lack of enthusiasm or energy.

Dosage

It is suggested to take an Pramiracetam dose of 1,200 mg that can be divided into 3 to 1 servings within a day. The half-life of Pramiracetam is 4.5 up to 7.5 hours. The first dose can be 250 mg, and then increase to 400 mg daily.

The best way to dosing is to take it early in the morning, later in the afternoon, and then later in the late afternoon.

5. Phenylpiracetam: The Most Stimulating Racetam?

Phenylpiracetamwas created in 1983 to be an even more potent racetam medication as compared to Pramiracetam to improve physical and mental performance. Similar to Pramiracetam, Phenylpiracetam adds to the amount of acetylcholine GABA, NMDA, and dopamine receptors found in the brain.

It’s unique because it is a Piracetam derivative that has an additional phenyl group within its structure. This extra phenyl group means phenylpiracetam is more efficient and bioavailable than piracetam itself. It is able to traverse the blood-brain barrier more quickly than piracetam, so has faster-acting effects.

Benefits and Side Effects

Phenylpiracetam nootropics enhance concentration, cognition, alertness, and mood. It also reduces anxiety and fear in social situations, and depression. Additionally, it has a unique method of increasing someone’s tolerance to cold and pain.

The physical strength benefits of the use of Phenylpiracetam drugs has made it one of the nootropics for energy.

It is among the top of the racetam family of supplements for athletes because of its superior power in stimulating.

Research has proven that it is also a successful treatment for epilepsy because of its anti-convulsive properties.

The most well-known negative effects of these kinds of drugs include headaches, irritability and irritability, as well as sleepiness, and sensory overload. Rarely, they can cause aggression increased anger, suicidal ideas.

Dosage

Phenylpiracetam is recommended to take between 100 mg to 200 mg a daily, once or three times a day.

The racetam users claimed that they felt the effects within 30 minutes after taking it. This is due to its bioavailability function. Phenylpiracetam’s drug is estimated to last 3 to 5 hours of half-life. It is possible to take in the morning, with one dose and another Phenylpiracetam dosage in the afternoon.

6. Coluracetam: The Strongest Racetam

Coluracetamis is one of newest racetam drugs developed in 2005, which functions similarly to Pramiracetam.

It boosts choline levels via the HACU system, which is responsible for an enzyme in the brain that converts choline into Acetylcholine. This leads to better memory development and learning.

Coluracetam nootropics can also enhance glutamate’s efficacy in the brain, which results in improved concentration and focus.

Benefits and Side Effects

Coluracetam racetams are extensively utilized to improve memory and for better studying. The majority of neurohackers prefer this medication due to its enhanced abilities to hear and color. It is also able to be used to treat depression, ease anxiety, relieve stress and also improve eyesight.

Coluracetam racetams’ main advantage is their ability to restart their HACU system for patients with brain disorders even after damage to their nerve cells.

Coluracetam is a well-known neuroprotective properties that shield the brain from Alzheimer’s disease. It also assists those suffering from strokes, trauma brain injuries, as well as other brain-related illnesses.

Brain fog, mood swings depression, unpredictable results due to not getting adequate sleep and taking greater doses are some of the adverse effects of Coluracetam racetams.

Dosage

The recommended dosage for this drug is between 10 and 80 mg. It should be taken between 1 and 3 times per day.

Coluracetam is a typical drug with three-hour half-life. It is crucial to remember that the higher dose should be divided into three or two smaller doses. The first dose should be taken first thing early in the day, and the second in the afternoon, and then in the late afternoon.

To determine the right dosage that is in line with your needs It is recommended to consult an expert in medicine.

7. Nefiracetam

Nefiracetam was developed in the 1990s as a racetam that is fat-soluble for treating cerebrovascular diseases.

Studies have shown that it increases the nicotinic receptors, which increase GABA release as well as GABA.

These processes enhance neuroplasticity, learning and memory development with the effect of calming.

By enhancing GABA signal, this helps in stabilizing the mood of a person and social sociability.
Nefiracetam also permits a longer opening of calcium channels that allow neurotransmitters more active.

Benefits and Side Effects

Nefiracetam enhances the recall of memories and also helps in formation. Many students have reported that Nefiracetam is the best efficient racetam to study with an unflinching focus.

Users have reported greater motivation and have a longer concentration, and have less fatigue and mental apathy.

Some people have claimed to are more articulate and have improved speaking abilities when they use the most effective nootropics.

It also features unique visual effects. The users described their visual range as being broader and nature appearing more appealing and vivid.

Concerning the possibility of developing hazards or toxicities There aren’t enough human studies. The studies are limited to dogs where higher doses have been proven to be harmful.

Dosage

The typical dosage of Nefiracetam can range from 150-900 mg per day. The smaller doses are a possibility such as 400 mg in the morning, and another one in the afternoon. Some people divide the larger dosages in three equally portions.

Nefiracetam causes a response to the brain within 30 to 60 minutes consumption.

Another point to be noted is that Nefiracetam can cause significant improvement in mood by taking 600-900 mg daily for 12 weeks, as it was in an American study of 159 patients suffering from stroke suffering from severe depression.

Best Racetam For Studying

Nefiracetam is probably the single best racetam for studying. While other racetams primarily increase focus, Nefiracetam increases neuroplasticity and reduces anxiety; two things which make learning new information much more efficient.

Of course, most of the leading racetams are going to be effective for making studying easier and more successful. You just need to pinpoint what aspect of studying you struggle with most and then choose a racetam accordingly.

Best Racetam For Motivation

It is hard to select the most effective racetam for motivation as no nootropics in the racetam class have a meaningful effect on motivation levels or drive. Racetams typically work on the cholinergic and GABA systems in the brain, or by increasing neuroplasticity and neurotrophic factor expression. As such, racetams are not typiclaly associated with increased motivation.

However, there is one exception to this. Phenylpiracetam has been found to increase dopamine activity in the brain. The effect is only slight, but it does seem to be the case that phenylpiracetam can increase motivation by increasing activity at dopamine receptors. If you are struggling with motivation, phenylpiracetam may help, although there are far better options out there. Natural nootropics can boost motivation far more effectively than a racetam.

Best Racetam For Anxiety

The best racetam to take for anxiety is probably Aniracetam. This is usually held as the leading racetam for anxiety, social anxiety and chronic stress. Studies have shown that Aniracetam lowers reported stress and anxiety levels in a number of contexts. In the linked study, researchers even found that Aniracetam was more effective at reducing different kinds of anxiety than diazepam, indicating that it has a number of anxiolytic effects.

Again though, using racetams to reduce anxiety is not an optimal strategy. There are natural nootropics which lower anxiety as or even more effectively than Aniracetam.

Best Racetam For ADHD

Using racetams to treat ADHD is not something to undertake lightly. If you have ADHD diagnosed by a medical doctor, it is vital that you follow their recommended treatment plan as they are best placed to know your physiology and symptoms and to manage them most effectively.

If you are an adult with some symptoms of ADHD, then using racetams may be beneficial. People with suspected undiagnosed ADHD have gotten great results from using racetams like Oxiracetam and Aniracetam due to their ability to rapidly sharpen focus, increase attention span and produce a calm state of mind.

Best Racetam Stack

The best racetam stack is different for eveyrone. It all depends on what nootropics you respond well to and what you are hoping to achieve. For exmaple, a great racetam stack for someone looking to boost mental energy and focus would be phenylpiracetam powder stacked with a cholinergic like citicoline and maybe a theanine/caffeine combination. Another great racetam stack would be Piracetam and Lion’s Mane Mushroom, which would boost short term and long term mental performance.

What is important is that you DO NOT STACK MULTIPLE RACETAMS together at the same time. Rather than taking racetams together, you should identify the best racetam for your needs and take that at an appropriate dose.

Which Racetam is Best for You?

If you’re just beginning to learn about racetams and want an extensively used, tested to be secure in its ability to boost cognitive function, that has been extensively studied over the years and has numerous advantages, Piracetam will suit you.

It is possible to choose between Aniracetam and Oxiracetam racetams to take a more comprehensive, powerful and innovative method of thinking.

For the relief of depression and anxiety, Aniracetam may help with its anti-anxiolytic properties and Phenylpiracetam as well as Coluracetam.

If you’re an undergraduate, Oxiracetam could be the ideal racetam to help your studies because of its stimulant effect. It is also possible to consider Nefiracetam as well as Pramiracetam. Phenylpiracetam is the most effective of all racetams for its anti-depressant and physical strength effects.

Coluracetam Nootropics are the ideal option for those who’d like to improve their hearing and sense of vision to be able to see vibrant colours and clearly hear.

To improve your speaking ability, articulate thinking and fluency in speech, you can try Nefiracetam, Pramiracetam, or Piracetam nootropic.

Many racetam enthusiasts create their own racetam stacks, and then combine two or three racetams.

A good illustration is an example is the Aniracetam Oxiracetam stack but keep in mind that these are subject to more research and a physician’s guidance to help you in the right direction.

Conclusion: What is the best racetam?

Racetams are among the most popular medications for various cognitive effects since they are generally considered to be secure.

A few studies have proved that some racetams can be effective, but the majority of claims come from neurohackers and user-friendly enthusiasts.

It is recommended to consult a physician regarding which racetam are most suitable for you and with the right dosage.

A much safer option is to use natural nootropic stacks instead of racetams such as nefiracetam and aniracetam which have powerful and often unpredictable effects, not to mention long-term side effects.