Before we delve any deeper into this topic, we need to say that developing any kind of tolerance to Modafinil is rare. If you find that you’re getting diminishing returns from Modafinil, then it’s highly likely that you are either taking far too much of the drug or you are using it far too often. Either way, having any kind of tolerance to Modafinil is not good sign!
That said, it does happen. Often.
Even though there is no clinical evidence that tolerance develops to modafinil, there is no shortage of anecdotal reports from heavy users who say the drug has simply stopped working. Or at least, stopped working like it used to.
Indeed, in theory it is easy to imagine why a tolerance to Modafinil might develop (more on the pharmacodynamics of Modafinil later).
What is less easy to imagine is what you should do about it!
In this article, we’re going to look at whether it is really possible to build a tolerance to Modafinil, and what you can do to reset your tolerance once it happens. We will explain how Modafinil works and how tolerance builds, before giving you some techniques on avoiding or resetting the potency of the drug for you.
What is Modafinil?
Modafinil is probably the single most widely-used and best-known nootropic smart drug in the world today.
Some drugs are more widely abused than Modafinil, and some of these could be considered cognitive enhancers or study aids. But in terms of true nootropics, Modafinil is arguably the archetypal example and the most popular.
Modafinil is a pharmaceutical drug with indications for various sleep disorders, such as narcolepsy, excessive daytime sleepiness, and shift work sleep disorder. When prescribed inside the United States it is typically given as Provigil. As well as the prescription-only Provigil form, there are dozens of generic Modafinil products on the market, such as Modalert, as well as generic Provigil made in India (global leader in branded medicine copying!).
Aside from its use as a drug for treating sleep disorders, Modafinil is also used as a cognitive enhancer.
When used by peolpe who do not have a sleep disorder like narcolepsy, Modafinil acts as an extremely powerful wakefulness and alertness booster. It also has secondary effects including increasing motivation, accelerating processing speeds and enhancing concentration.
Within an hour of taking Modafinil most users feel dramatic improvements in their ability to stay focused on tasks and get things done. It isn’t uncommon for people to take a single tab of Modafinil and to spend the next 8 hours hyper-focused and locked-in on work. It is particularly useful when working through the night since it completely negates the desire to sleep.
So how does Modafinil do this exactly?
What does Modafinil do to the brain?
How does Modafinil affect the brain?
While Modafinil is often described as a central nervous system (CNS) stimulant, it differs significantly from classical psychostimulants in that it doesn’t not produce euphoria or the side effects associated with stimulants. Rather, Modafinil is more accurately described as a eugeroic. This means it is a wakefulness and alertness promoting agent.
While there is some disagreement over exactly how Modafinil promotes wakefulness and enhances cognition, it is almost certain that its primary mechanism of action involves dopamine.
Modafinil and prodrugs of Modafinil like Fladrafinil are known to act as selective dopamine reuptake inhibitors. This means these smart drugs increase the total amount of dopamine available at your neurons, which in turn will massively increase motivation, focus, and overall cognitive performance.
There is also evidence that the drug indirectly activates the release of both orexin neuropeptides and histamine. Together this would account for Modafinil’s powerful wakefulness promoting and anti-fatigue effects.
Can you build a tolerance to modafinil?
Tolerance develops over time with repeated use of a substance, whether a prescription drug or a recreational one. Over time, the body becomes accustomed to the drug, requiring larger doses to get the same effects. This can become a major problem and requires a remedy. Modafinil is no exception. If you’re concerned that you’ve built a tolerance to Modafinil, here are some tips to help you avoid it.
While the science behind Modafinil tolerance has not yet been fully understood, it is known to occur in everyday users. It’s not yet known whether Modafinil tolerance develops, but the onset of this condition has been observed in people who regularly take the smart drug. The key to avoiding tolerance is to cycle off Modafinil frequently and use alternative nootropics to replace it.
While taking Modafinil isn’t an instant solution, you should gradually increase your dosage until you feel the effects subside. It may take a few weeks for the body to adjust to it. A dose of 100 mg a day will only have a minimal effect on the body. But be sure to consult with your doctor before reducing the dosage. Likewise, if you develop a tolerance, the dosage should be reduced.
Can Modafinil just stop working?
What if your Modafinil simply stops working?
It is pretty much unheard of for Modafinil to just stop working. If you feel like you are no longer getting the same effects from Modafinil, there are a few things you can do.
The most likely explanation is that you are buying low quality Modafinil that does not have a uniform dose of active compound. Make sure you buy Modafinil from the best online pharmacy; we recommend Modafinil XL, both for reliability and prices.
It is also possible that you are using Modafinil so much that you are no longer really noticing the power of its effects. This could be described as a kind of psychological tolerance to modafinil. It is extremely rare, but possible. However, it should go away very quickly if you take a break from the smart drug.
The biggest concern if your Modafinil has suddenly stopped working is that overuse has downregulated your dopamine receptors. Modafinil works by increasing dopamine availability between your synapses. This can overwhelm and even damage dopamine receptors over time, leading to decreasing effectiveness of Modafinil.
If your Modafinil has seemingly stopped working, do not increase the dose. Taking more Modafinil is not the answer. Modafinil is not massively dose-dependent; above the active dose, more Modafinil doesn’t produce stronger results but it does make side effects more likely.
Can you take modafinil long-term?
Can you take modafinil long-lasting? That’s a question that plagues those who suffer from sleep apnea and narcolepsy. While a few studies have shown that modafinil can improve the symptoms of a patient’s sleepiness, more studies are needed to determine its potential for long-term use. To answer this question, we need to know how much you need to take.
In one randomized trial, Modafinil increased dopamine levels in the nucleus accumbens in an awake, freely moving guinea pig. In other studies, modafinil inhibited gamma-aminobutyric acid outflow from the cerebral cortex of awake, freely moving guinea pigs. It may also involve 5-hydroxytryptamine mechanisms, as suggested by the Thase ME study of SSRI therapy in patients with fatigue and excessive sleepiness.
Modafinil has numerous potential treatment targets. Because of its effects on activity and arousal, it has been investigated as a treatment for cognitive dysfunction in patients with neuropsychiatric disorders. While it has already been studied extensively for its effects on arousal and activity, modafinil’s pro-cognitive effects are still understudied. In the meantime, many people who use modafinil have reported improvements in their overall mental health, including working memory, episodic memory, and other cognitive functions.
How long does modafinil tolerance last?
Tolerance develops when a substance is used over a period of time. This can be the case for caffeine, sugar, or prescription or illegal drugs. Over time, the body becomes used to the drug and requires higher doses to achieve the same effect. Modafinil tolerance occurs when a user’s body adjusts to a drug’s presence in the body. To counter this effect, he or she may take drug holidays or take a medication break to avoid drug tolerance.
For daily users of Modafinil, this issue is very real. Although it has not been proven scientifically, this phenomenon is recognized in the unregulated world of nootropics. In fact, a modafinil tolerance may develop after several days or weeks of use. In this case, the user should take Modafinil only when it is needed. This way, a person does not need to increase the dosage of the drug or go on a drug holiday in order to regain their sensitivity.
While Modafinil tolerance develops in the body over time, there are some possible side effects when you first start using it. These side effects may occur for several weeks as your body adjusts to the drug. However, these effects will subside after a few weeks. A person’s tolerance for Modafinil is determined by the individual’s age. Some people may develop a tolerance for Modafinil within a month. This happens when you use the drug too frequently.
Can you reset your tolerance to Modafinil?
Can you reset your tolerance to Modafinile? You can do so by taking a small amount of the drug a few days a week. This way, you can avoid the risks associated with developing a tolerance to the drug. In addition, if you skip a dose for a week or two, you can avoid developing a tolerance to the drug. If you’re having trouble sleeping, try skipping your dose for two to four days.
Long-term users of Modafinil may develop a strong tolerance to the drug and find that it doesn’t have the same focusing effects. In this case, it may be time to cut back your dose and try again. However, if you’re taking other medications, Modafinil may clash with them. Therefore, it’s best to reduce the dose of your current medication until you can get the same results.
To reset your tolerance, the first thing you should do is try to sleep for at least six to seven hours without any interruption. You can use a 200-mg tablet in the morning or over the weekend. Do not drink anything after swallowing the pill. Try to fall asleep within a few hours and wake up normally the next day. If you don’t feel rested and awake after a night of Modafinil, consult a doctor to discuss your treatment options.
Taking a Modafinil Tolerance Break
Taking a Modafinil tolerance-break is a necessary step for avoiding the risk of developing a tolerance to the drug. Tolerance develops over time. It is possible to develop a tolerance in as little as one month and as much as a year. During this period, users are encouraged to take the drug no more than 1-4 times per week. However, if a person is taking Modafinil daily, it may be best to take a break for at least two weeks.
The exact mechanism behind this phenomenon is not yet fully understood, but anecdotal evidence suggests that the drug may not work as well as it did in the beginning. Modafinil tolerance is not a sign of addiction or dependency, but it is a warning sign that a person is reaching a point of physical and psychological dependence. Therefore, taking a Modafinil tolerance break may be necessary in order to avoid the side effects of the drug.
To avoid the risks of developing a Modafinil tolerance, it is best to stop taking the drug for seven days a week. In addition, taking Modafinil for an extended period may lead to serious side effects. Some people experience increased fatigue, decreased attention span, short-term memory loss, depression, anxiety, and sleepiness. Modafinil is an extremely powerful stimulant and should be taken with caution.
Types of Modafinil Tolerance
To add complexity to the discussion, you need to know three types of drug tolerance [ 14]
- Pharmacokinetic clearance: The drug’s amount reaching its target site decreases as the body clears more of it.
- Pharmacodynamic tolerance: The drug does not react to certain receptors or the number of them is less.
- Behavioral tolerance: An individual learns to reduce the effects of a drug.
When Modafinil tolerance is developed, all three mechanisms occur simultaneously. Depending on who is using Modafinil, one mechanism might be more common than the other.
Modafinil users experience a decreased focus and energy compared to when they first took the drug. The benefits don’t seem as strong or are less than they used to be.
As we have said, drug tolerance can be reversed in many cases. A few simple tips can help you overcome your tolerance to Modafinil.
7 Quick Tips For Avoiding or Resetting Modafinil Tolerance
Here are some tips for Modafinil users who may be considering using it.
These tips are not ranked in any specific order. Please use your best judgement when deciding which one of these tips is most relevant to you. As contaminated or impure samples can lead to undesirable outcomes, we assume that you only use high-quality Modafinil from a licensed vendor.
Don’t Develop Any Tolerance To Modafinil In The First Place!
This is not an easy task, but it is important to take a proactive and preventive approach to ensure you don’t develop any tolerance to Modafinil.
This is not applicable to people who are new to Modafinil and related compounds, as they don’t have a “Modafinil tolerance”.
These tips will help you if you find yourself in this position right now. They have been proven effective in preventing Modafinil tolerance by many research subjects.
Like any other nootropic, Modafinil can be taken in moderation.
It is obvious that Modafinil can be taken in excessive doses for a number of days or weeks. This could lead to tolerance.
These are the rules that we follow when Modafinil is used as a smart medication responsibly
Modafinil should not be taken more than four times per week. Modafinil should be taken only once a week.
We take 100-200 mg daily for the best results.
Tolerance issues with Modafinil can be avoided by following the above rules.
Never Take Modafinil On Back-to-Back Days
We should follow the above recommendations and avoid taking the drug for consecutive days. Modafinil is taken 4 times per week. We want to spread our doses by at most one day.
Modafinil will be taken on Mondays, so we will wait until Wednesday before we try again.
Modafinil’s effects will not be affected if Modafinil is not taken on consecutive days.
People who have a problem with tolerance or smart drugs end up using them. This is when you take the same nootropic daily at extremely high doses and then increase the dosage when it “stops working”.
Take Regular Modafinil Breaks
Modafinil should be stopped if we have been taking Modafinil for more than four days per week for several months.
Research subjects who used the nootropic for around 2 months straight will stop using Modafinil for two weeks [ 15].
“… It takes approximately 3-7 days for the tolerance level to drop to half, and 1 – 2 weeks to return to baseline (in the absence any further consumption).
Modafinil might have a cross-tolerance to all benzhydryl nootropics. This means that all related eugeroic compounds, such as armodafinil or adrafinil, will show a decreased effect after modafinil consumption.
Your body will reset its Modafinil tolerance levels if you don’t consume the nootropic for at least two weeks. Modafinil users who have taken a break often feel that their strength has returned when they start to use it again.
A break of 1-4 weeks is usually enough to reset your tolerance to Modafinil.
Modafinil can be used in cycles of two weeks on, two weeks off for some users. This allows users to enjoy the greatest cognitive benefits and prevents them from developing a tolerance for Modafinil.
Users may also decide to reserve Modafinil for emergencies (all-nighters or shifts that last more than 24 hours, etc.). ).
Cycle Other Smart Drugs
Modafinil is not the only nootropic that one may need. However, smart drug users who are experienced will continue to use smart drugs.
This allows them not to be completely dependent on Modafinil or any other smart drug.
Modafinil users looking for a different type of cognitive boost will find many options.
NOTE: Armodafinil (a.k.a. Modafinil) can be used in place of Modafinil. Armodafinil (a.k.a. Modafinil) can be used instead of Modafinil. However, Armodafinil tolerance may also be possible. This guide has the same effectiveness as Modafinil tolerance.
Limit Other Drugs and Stimulants
It is highly recommended to rotate your nootropics regularly and to not use other smart drugs with Modafinil the same day.
This means that if Modafinil is being taken on one day, it should not be combined with Mind Lab Pro the next day.
Stimulants are subject to the same rules. Combined with the wakefulness-promoting properties of Modafinil, the increase in energy levels may be too overwhelming for some users.
Others have reported mixed results with Modafinil and fresh Organic Coffee (maximum of 1-2 cups) on the same days. However, these are our personal recommendations.
Supplement with Magnesium For Reduced Modafinil Tolerance
Some experimental data suggests that magnesium supplementation may lower one’s tolerance to addictive drugs [ 16]
“Magnesium decreases the intensity of addiction with opiates (cocaine and amphetamines, nicotine, and other psychostimulants).
It reduces auto-administration of cocaine, relapse to cocaine and amphetamine use, and also reduces experimental addiction to morphine and cocaine in animals.
Apart from the magnesium ions’ action during emerging addiction, withdrawal syndrome symptoms are less severe when this cation is administered.
Supplementing with magnesium and ceasing to use Modafinil may be an option if you have already experienced issues with dosage and tolerance.
There are many ways you can consume magnesium. Magnesium oil seems to be the most convenient.
Can Grapefruit Help With Modafinil Tolerance?
Some of you may have heard that grapefruit is good for preventing Modafinil tolerance. While there is an element of truth in this statement, it isn’t actually correct.
Grapefruit is known to inhibit the enzyme CYP3A4. This is the enzyme that breaks Modafinil down in the liver and ultimately allows your body to eliminate it. So by inhibiting CYP3A4, grapefruit prevents the breakdown of Modafinil. This means more Modafinil stays in your system for longer, prolonging its effects and making it much more powerful overall.
So grapefruit does help make Modafinil feelmore potent, but that is not the same thing as preventing the build up of tolerance! Eventually, you’ll just be taking more and more grapefruit to try and keep the effects of Modafinil the same!
Paul Tardner is the Head Writer at IJEST.org. Paul is a former academic and research scientist. He now dedicates his time to his own research into nootropics, with a particular focus on cognitive enhancement in old age. You can learn more about Paul from his profile page.