Noopept tolerance is a major conern for regular users of this extremely popular nootropic.
Like all brain supplements and study drugs, Noopept tends to be used by people on a regular basis. Some people use Noopept every single day, while even casual users tend to take Noopept at least a couple of times a week.
With peolpe usin this drug so frequently, it’s worth considering whether or not it is possible to develop any kind of tolerance to Noopept, and how this might affect the efficacy of the nootropic.
Is there such a thing as Noopept tolerance?
How can you avoid developing a tolerance to Noopept?
Let’s take a closer look at what Noopept is, how it works, and what the side effects of Noopept are to answer this question properly.
What is Noopept?
Noopept is a nootropic drug, more formally known as Phenylacetyl-l-prolylglycine ethyl ester and someties referred to as GVS-111. It is sometimes called Omberacetam, which is the proposed INN for the drug, although this is far from ideal as Noopept is not a racetam!
Noopept is frequently referred to as a racetam because it is ver similar to Piracetam in both structure and effcts.
However, it is not a racetam as it lacks the formal requirements of being classed as a racetam. But its development was based on the structure of Piracetam, so the two nootropics are intimately related. In fact, Noopept and Piracetam have very similar effects, so the link certainly makes sense.
So what does Noopept do exactly?
What does Noopept do?
Noopept works in a vey straightforward way which makes it produce very broad cognitive enhancements.
Noopept is a prodrug of cycloprolylglycine. Cycloprolylglycine is a neuropeptide which controls the release of another neuropeptide, Brain Derived Neurotrophic Factor (BDNF) in the human brain.
Increasing cycloprolylglycine has been shown in numerous clinical trials to increase the expression of BDNF in the brain.
This is important, as BDNF is responsible for reglating the prolieration, maturation and maintenance of neurons. Higher levels of BDNF in the brain trigger an increase in neuron growth, proliferation and maintenance. This has profound effects on cognitive performance, as interneural communication is the ver essence of cognitive function.
Simply put, higher BDNF levels means more raw brain power, which means increased focus, attention, learning, processing speeds, and memory function.
Some studies have also found that increasing BDNF effectively improves mood and reduces anxiety.
Can you build a tolerance to Noopept?
The simple answer is no, you cannot really develop a tolerance to Noopept or any of the similar racetams.
In fact, the opposite is the case; Noopept should actually work better with regular use over time, since it works y boosting BDNF and, by extension, brain cell development.
Some Noopept users do report feeling fewer effects after using Noopept on a daily basis for 6-12 weeks. However, it is hgihly likely that they are simply now used to the effects of Noopept and are no longer noticing the difference between their baseline selves and their new cognitively enhanced states.
Another possibility is the initial placebo effects that everybody experiences when using powerful nootropic study drugs like Noopept for the first time. These effects subsiding is not the result of tolerance building, but rather just the placebo effect withering.
So no, you should not be able ot develop a tolerance to Noopept. Nor to any of the related drugs like the racetams.
Paul Tardner is the Head Writer at IJEST.org. Paul is a former academic and research scientist. He now dedicates his time to his own research into nootropics, with a particular focus on cognitive enhancement in old age. You can learn more about Paul from his profile page.