Noopept and Piracetam are arguably the two most popular nootropics in existence, with the possible exceptions of Modafinil and Adderall. Most biohacking websites list these two substances as among the best nootropics in the world.

Indeed, both Noopept and Piracetam have well demonstrated nootropic effects. There are dozens of studies showing that both Piracetam and Noopept have significant positive effects on cognitive fuction, and users will attest that both nootropics are stronger than natural nooropic stacks such as Mind Lab Pro.

You will often see Noopept and Piracetam spoken about together. Many people even refer to Noopept as a racetam, even though it isn’t; Noopept has a similar structure to Piracetam (and is in fact based on it), but it doesn’t have a racetam structure.

But which of these nootropics is the best?

In a fight of Noopept vs Piracetam, who comes out on top?

Should you be using one of these nootropics over the other? Or do they have distinct benefits?

Let’s take a closer look at both Noopept and Piracetam, their benefits, mechanisms of action, and side effects, to see if one is better than the other.

Noopept and Piracetam: Similarities

Noopept and Piracetam are very similar in terms of the benefits they provide.

Both Piracetam and Noopept are associatd with the same subjective effects, which include:

  • Enhanced focus and concentration
  • Reduced anxiety and increased confidence
  • Improved verbal fluency
  • Better overall brain health
  • Improved working memory function

It is obvious to see why Noopept and Piracetam are both such widely-used nootropics. They both confer a wide range of benefits to the end user; benefits which broadly encompass almost every aspect of brain performance.

But how do Piracetam and Noopept differ?

Noopept vs Piracetam: Dosage

This is where every Noopept vs Piracetam comparison needs to focus, as the biggest difference between these nootropics is the minimum active dose.

Noopept has a much smaller minimum active dose than Piracetam.

As a general rule of thumb, you will get the same benefits as 1,000mg of Piracetam when using just 15-20mg of Noopept.

That means that Noopept is roughly 50-100 times more potent than Piracetam by weight.

So if you value being able to take as little of a given substance as possible, Noopept is the standout winner here. But if you don’t mind consuming 1-2g of Piracetam, then it really doesn’t make much of a difference!

Noopept vs Piracetam: Mechanism of action

While Noopept and Piracetam have very similar effects in terms of subjective user experience, these nootropics are not thought to work in the same way.

In other words, Noopept and Piracetam have completely different mechanisms of action.

Noopept is thought to work priarily by boosting Brain Derived Neurotrophic Factor (BDNF).

BDNF is a primary neurotrophic factor; it controls the growth, proliferation and maintenance of neurons. By raising BDNF levels in the brain, Noopept increases neuron growth and proliferation, which essentially gives your brain more raw computing power to work with.

Having higher levels of BDNF has been shown to lead to signficiantly improved focus, btter memory function, improved mood, and reduced anxiety. What’s more, the benefits of raising BDNF should last for a long time, since it leaves you with greater neuron density and better neuron health.

Piracetam, on the other hand, primarily works by potentiating acetylcholine activity. Piracetam may modulate muscarinic cholinergic receptors, thus increasing the action of acetylcholine, which is the brain’s main executive neurotransmitter.

There is also evidence to suggest that Piracetam works by affecting NDMA glutamate receptors; neurotransmitter receptors that are heavily implicated in mental energy, focus and learning.

I should say that there is constant debate about how these nootropics work. The mechanisms of action that I have presented here are based on the best evidence currently available.

So which os these two nootropics wins in terms of mechanisms of action?

Well, I have to give this one to Noopept too.

Piracetam primarily seems to work by potentiating neurotransmitters via their receptors. This means that the benefits of Piracetam diminish very quickly, and disappear altogether not long after you stop taking it. The benefits of Noopept, on the other hand, should be much longer lasting since they come from increasing neuron density and health.

Noopept vs Piracetam: Side Effects

Which is safer, Noopept or Pracetam?

This might be the most important part of any Piracetam vs Noopept article, even if it is not the part that most people are interested in!

Generally speaking, both Noopept and Piracetam are safe to use in reasonable doses and for limited periods of time.

Neither Noopept nor Piracetam routinely cause serious side effects (when used correctly).

When side effects do occur, they are typically mild and they dissipate once you stop taking the nootropic in question.

Both Noopept and Piracetam have very similar side effects. Typical side effects associated with both Noopept and Piracetam are:

  • Depression
  • Agitation
  • Anxiety
  • Insomnia
  • Paranoia
  • DIzziness
  • Nausea
  • Headaches
  • Stomach cramps
  • Diarrhea

These side effects become much more likely if you use ver large doses of Noopept or Piracetam, or if you use them for prolonged periods without break. Mixing them with other nootropics and stimulants will also increase side effect severity

As I stated above, if you do experience any of these side effects while using Noopept, Piracetam, or any other nootropics for that matter, stop using them immediately and seek urgent medical attention.

Piracetam vs Noopept: Which is better?

In Noopept vs Piracetam, who wins?

Which is the better brain supplement?

Which nootropic better enhances cognitive performance?

Th answer really depends on what it is you want to get from your nootropics.

If your goal is just short term increases in focus, learning and information processing, Piracetam is probably the better option for you. This nootropic is short-lasting, and it focuses exclusively on executive cognitive functions.

If you want more overall brain support from your nootropic, then Noopept is probably the right call. Noopept has more wide-ranging benefits, including reduced anxiety and improved mood. The effects of Noopept are also longer lasting owing to its unique mechanism of action.

So which nootropic you choose to use depends on what you re lookin for.

But if you want maximum cognitive enhanement, total brain health support, and no side effect risks, then I strongly recommend using high quality natural nootropic stacks like Mind Lab Pro.

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About the Author P. Tardner

Paul Tardner is the Head Writer at Paul is a former academic and research scientist. He now dedicates his time to his own research into nootropics, with a particular focus on cognitive enhancement in old age. You can learn more about Paul from his profile page.