Mixing Modafinil and Alcohol | What You MUST Know

Modafinil is a medication prescribed to those suffering from sleep disorders, as well as narcolepsy and shift work sleep disorder. It’s also used by athletes in order to increase their focus and performance. There are many benefits of consuming modafinil while drinking alcohol like it enhances the effects of intoxication or decreases its negative side-effects such as impaired motor function, memory loss, etc…

Mixing Modafinil and Alcohol | What You MUST Know

Modafinil is a medication used to treat narcolepsy, sleep apnea and shift work disorder. It can also be used as a cognitive enhancer or for jet lag. Alcohol interacts with modafinil in the liver by inhibiting its metabolism. This leads to increased levels of modafinil in the blood, which can cause severe side effects such as dizziness, confusion, and nausea.

Is it safe to combine Modafinil with alcohol?

That, of course, depends on who you ask.

Although the research isn’t conclusive, common sense says NO! It is not healthy to take Modafinil and then consume alcohol. In reality, it’s the polar opposite.

We’ll break down everything you need to know about boozing and Modafinil in this comprehensive guide. We’ve looked at the few research papers on the subject, as well as user experiences.

Below is all you need to know to be safe while combining these drugs.

 

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What Does Modafinil Do?

To properly comprehend how Modafinil works, we must first examine its history and the reasons for its creation.

Modafinil was developed in France in the 1970s as a pharmaceutical-grade wakefulness medication with the goal of making it very difficult to feel tired or fall asleep [1].

The medication was developed for those suffering from sleep disorders such as [2]:

  • Narcolepsy
  • Significant sleep apnea
  • Sleep apnea syndrome

When the prescription medicine arrived in the United States, doctoral students, startup CEOs, and other high-achievers started to recognize Modafinil’s bizarre off-label applications.

Off-label applications and advantages include [3]:

  • Ability to concentrate for more than 12 hours
  • Side effects are minimal.
  • Improved memory recall and retention
  • Overall, cognitive function has improved.
  • Increased daily production and productivity
  • Increased happiness and well-being

Individuals would use Modafinil as a smart drug or nootropic off-label. Many individuals who used Modafinil for these objectives described their brain as “supercharged,” helping them to stay ahead of the competition.

This is why Modafinil has become so well-known.

Because the nootropic promises crazy cognitive advantages that will help you get more done, better your university grades, and/or generate more money.

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How Does Alcohol Function?

You have a rudimentary understanding of how alcohol affects the mind and body…

People drink to unwind, enjoy social gatherings, and feel liberated, among other things. In most circumstances, it’s a social “drug,” and it’s seldom used for “concentration” or anything like.

While modafinil increases productivity, alcohol has the reverse effect.

Nobody is more productive while they are inebriated than when they are sober. Except for alcoholics, of course. Alcoholics with a purpose.

Alcohol acts as a depressive in the body and brain [4]. While Modafinil isn’t strictly a stimulant because of how it works in the brain, there’s no disputing it produces stimulant-like effects.

As a result, modafinil and alcohol are polar opposites. There’s an upper and a lower.

While Modafinil works by stimulating neurons that make us feel more focused and alert [5], alcohol works by attacking neurotransmitters that make us feel relaxed, unrestrained, and even exhausted [6].

Both alcohol and Modafinil [7] have an effect on two neurotransmitters in the brain [8]:

  • GABA
  • Glutamate

However, they have distinct effects on these neurotransmitters, which may be harmful.

GABA activity in the brain is increased by alcohol, whereas Glutamate synthesis is decreased. Modafinil has the exact opposite effect.

 

What Studies Say About Modafinil and Alcohol

We don’t advocate taking Modafinil with alcohol since it confuses your brain and neurotransmitters. Mixing alcohol with prescription medicines is a risky combination that may lead to serious consequences.

We’re not the only ones that believe this. Many doctors have spoken out against the practice. It’s even told explicitly forbidden to do this [2]:

When using Modafinil, avoid consuming alcohol.

In all of the material I’ve seen, however, there is seldom much justification offered to the “why?” Many websites claim that combining alcohol with Modafinil is dangerous, but they don’t explain why. Mixing prescription medicines and alcohol is usually thought to be a bad idea.

This is the best practice in general. Do not combine prescription medications with alcohol.

The consequences were studied in depth, but the findings were never published [9]:

This research should be ended since it was completed before 2007 and the investigator has now retired. There are no records available.

Overall, there isn’t much evidence available in the medical community on the effects of drinking while taking smart medicines.

It’s generally thought to be a terrible idea. Doctors don’t want individuals combining prescription medications and alcohol, but often don’t explain why.

When we consider the facts above about GABA and glutamate, though, it’s clear where the risk resides.

Modafinil and alcohol have diametrically opposed effects on the brain. As a result, the level of stress placed on your neurons when these two chemicals are combined is just too much. When these two powerful chemicals are combined, your brain enters the “danger zone.”

 

 

When combining alcohol with modafinil, there are risks.

So, what are the drawbacks of combining Modafinil with alcohol? What are the disadvantages of such a combination? Let us investigate.

Here are some personal experiences:

  • You Feel Fine: Depending on how you look at it, this might be a good or bad. It may be hazardous in any case. You’ll typically feel wonderful after drinking alcohol after taking Modafinil. You’ll get the benefits of the alcohol without any of the drawbacks. This often leads to binge drinking since people feel fine and are unaware of how inebriated they are. This generally leads to individuals drinking much more than they should.
  • While you won’t notice it, many people report becoming drunk faster when they take Modafinil. The “body” will get inebriated, but the intellect will be unaffected. Modafinil inhibits hunger. As a result, many users who take the smart medicine don’t eat much throughout the day. Then they go out late at night drinking, and owing to the absence of food in their stomach and the smart medication, they become inebriated considerably quicker. The issue is that it’s almost hard to tell how inebriated you are when taking this nootropic.
  • Getting Sick: When combining alcohol with Modafinil, many users describe excruciating hangovers. Some people claim to be unwell for a few days after taking a cocktail of smart medications and alcohol. That is not acceptable. It is not advised to drink heavily after taking 200 mg or more of Modafinil, since the hangover might be excruciating.
  • Modafinil has a very lengthy half-life. If you take the tablet at 7:00 a.m., the effects will last until midnight. That a result, you can’t take Modafinil on the same day as you intend to drink and expect the two chemicals to stay separate. Modafinil does not function like that.
  • Not advisable: Last but not least, this combination has never been prescribed by a doctor. If you want to keep things simple, avoid combining these two drugs whenever feasible. It’s difficult for the body to process smart medications and alcohol at the same time.

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Any advantages?

While combining alcohol and Modafinil is not advised, there are certain advantages to doing so.

Others have mentioned the following advantages:

  • Unable to Blackout: When this nootropic is used with alcohol, blackout may be almost impossible. You won’t have to worry about passing out or forgetting what occurred over the night if you drink a lot. Modafinil increases cognition in both sober and inebriated people.
  • Increased Tolerance: Modafinil raises your tolerance to alcohol. Because your mind won’t feel inebriated, you’ll be able to drink more than normal after a day of utilizing the nootropic. Some people see this as a plus, particularly if they want to rant all night.
  • While we don’t recommend boozing on Modafinil, many people swear by it when they have a hangover. Nothing beats waking up feeling terrible and taking 200 mg of Modafinil. Instead of lazing in bed all day, you’ll be useful in two hours.

 

 

Three Specific Circumstances

Now that you know a bit more about combining Modafinil and alcohol, let’s look at three distinct ways individuals combine the two powerful medications.

Modafinil and alcohol are often combined as follows:

Drinking the Day After Modafinil Use

This should not be a problem. The half-life of modafinil is just around 15 hours. If you take Modafinil and sleep, then get up the following day and start drinking, the smart drug’s effects will have worn off.

You’ll be able to drink normally without experiencing any side effects, intoxication, or hangover.

While Modafinil may be damaging to the immune system, so can alcohol. Avoid cramming too many of these days into one day.

After Taking Modafinil in the Morning, Drinking

This seems to be the most typical scenario.

Someone takes the smart medicine in the morning and then drinks with their companions later that evening. Modafinil’s effects are still active in these settings owing to its half-life.

Your tolerance levels will rise, and you should be alright, but you may get inebriated more quickly owing to a lack of food. The excessive drinking that Modafinil permits sometimes results in a terrible hangover the next day.

After Taking Modafinil, Drinking

Some people claim to have taken Modafinil just before a big night out. Users who combine Adderall and booze to guarantee they can party all night are doing something similar.

No matter how much alcohol you drink, modafinil will keep you awake for hours.

This is not a good idea.

You may find yourself unable to sleep because you are so inebriated that your body requires you to pass out. It may be risky and unpleasant. This should be avoided.

 

The Verdict on Modafinil and Alcohol

Mixing liquor with smart medicines is not encouraged in general.

It’s just not good for the body, particularly when done often. Make the most of your Modafinil time by doing useful things and drinking on separate days.

The primary cause is…

When you combine alcohol and Modafinil, your chances of having hazardous side effects from both medications rise dramatically. Significant negative effects that are uncommon when the two drugs are used individually.

Modafinil is used in the workplace. Booze is meant to be enjoyed. Do not combine the two!

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References

  1. Staff, Edited by Editorial. “Can Modafinil Treat Cocaine Addiction & Amphetamine Withdrawal?” American Addiction Centers, americanaddictioncenters.org/addiction-medications/modafinil.
  2. “Indications, Side Effects, and Warnings for Modafinil.” www.drugs.com/cdi/modafinil.html. Drugs.com.
  3. “Mechanisms of Modafinil: A Review of Current Research,” by Paul Gerrard and Robert Malcolm. Dove Medical Press, Neuropsychiatric Disease and Treatment, June 2007, www.ncbi.nlm.nih.gov/pmc/articles/PMC2654794/.
  4. “What Alcohol Really Does to Your Brain,” by David DiSalvo. www.forbes.com/sites/daviddisalvo/2012/10/16/what-alcohol-really-does-to-your-brain/#721c8c20664e, Forbes Magazine, 12 Aug. 2015.
  5. “The Antinarcoleptic Drug Modafinil Increases Glutamate Release in Thalamic Areas and the Hippocampus,” by L Ferraro et al. U.S. National Library of Medicine, Neuroreport, 8 September 1997, www.ncbi.nlm.nih.gov/pubmed/9376524.
  6. Banerjee, Niladri. “Neurotransmitters in Alcoholism: A Review of Neurobiological and Genetic Studies.” Indian Journal of Human Genetics, Medknow Publications & Media Pvt Ltd, Jan. 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4065474/.
  7. “The Vigilance Promoting Drug Modafinil Decreases GABA Release in the Medial Preoptic Area and the Posterior Hypothalamus of the Awake Rat: Possible Involvement of the Serotonergic 5-HT3 Receptor,” by L Ferraro and colleagues. www.ncbi.nlm.nih.gov/pubmed/8977135, Neuroscience Letters, US National Library of Medicine, 6 December 1996.
  8. “GABA and Glutamate in the Human Brain,” by Ognen A C Petroff. U.S. National Library of Medicine, The Neuroscientist: a Review Journal Bringing Neurobiology, Neurology, and Psychiatry Together, Dec. 2002, www.ncbi.nlm.nih.gov/pubmed/12467378.
  9. “No Study Results Posted on Modafinil-Alcohol Interactions in Healthy Volunteers.” ClinicalTrials.gov, clinicaltrials.gov/ct2/show/results/NCT00305292, has no study findings.

 

 

Modafinil is a drug that has been used for the treatment of sleep disorders, and it’s also known to be very effective in the treatment of narcolepsy. It can also be used as a stimulant, but when mixed with alcohol, it can lead to some serious health issues. Reference: modafinil and caffeine.

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About P. Tardner

Paul Tardner is the Lead Author at IJEST.org. Paul is a former academic and research scientists. He now dedicates his time to his own research into natural biohacking, with a particular focus on cognitive enhancement.

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