Modafinil and Weed | What You MUST Know

Did you know that weed and Modafinil have a few things in common? Let’s look at what is actually happening with these two drugs.

Modafinil and weed are two substances that are often used together. However, the effects of modafinil and weed can be very different. In this article, we will discuss the differences between the two drugs and how they affect your brain.

Modafinil and Weed | What You MUST Know

Weed and modafinil.

Who in their right mind would think of such a mix? When you first glance at them, they seem to be polar opposites.

Weed is often associated with stoners who sleep late, eat excessively, and do nothing useful. Modafinil, on the other hand, is the perfect nootropic for anybody who desires to live the life of Edward Morra from “Limitless.”

But maybe we’re being too harsh…

Is it feasible that cannabis and Modafinil are a previously unknown duo that boosts productivity and creativity? Could it also help with sleep quality?

That is why we have created this tutorial. To go through all of the reasons why we would — or wouldn’t — combine Modafinil with marijuana.

However, before you begin reading, consider the following: 

Despite the global trend of cannabis legalization, cannabis and THC-containing products remain illegal to possess and consume in a number of countries, whether for medicinal or recreational use. This essay is solely based on our own experience and is just for amusement purposes. Before trying to get or use marijuana or THC-containing products, we highly advise you to verify and respect all cannabis-related laws in your area. 

Let’s get started now that it’s out of the way! 

 

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What exactly is Modafinil?

First and first, let’s address the obvious question: why is Modafinil so popular, and how does it work?

The Federal Drug Administration has categorized modafinil as a Schedule IV controlled substance. Modafinil is often prescribed by doctors to treat the following conditions:

  • ADHD
  • Narcolepsy
  • Apnea during sleep
  • Sleep disturbances in shift workers

After decades of research, we still can’t determine its present mode of action, making Modafinil a very complicated medicine with much more to learn about its real nature.

But, for now, here’s what we know [1]:

“It’s supposed to work largely by inhibiting the noradrenaline (NE) and dopamine (DA) transporters. Serotonin, histamine, gamma-aminobutyric acid, and glutamate are all affected.”

The impact of modafinil on orexin is thought to cause an increase in the hypothalamic release of histamine, which has arousal and alertness as one of its functions.”

People began taking modafinil for uses that were not officially approved, earning it a reputation as a cognitive enhancer. Specifically, to help with concentration, attention, and focus.

Adderall has lost favor as a research medication in recent years, perhaps owing to its worrisome safety profile. We believe that Modafinil is currently the #1 concentration drug for everyone in college or university, based on our conversations with thousands of our readers. It’s not without reason:

After doing thorough study, respected Harvard and Oxford experts dubbed Modafinil “the world’s first safe smart medicine” in 2015 [2]:

“Modafinil’s nootropic impact varied depending on the activity, but it was especially effective in boosting decision-making and planning, and it consistently gave higher advantages throughout longer and more complicated activities… 70% of research that took into account Modafinil’s influence on mood and other adverse effects found no impacts.”

So, where does marijuana fit into this scenario?

 

 

The Basics of Modafinil and Weed

We need to understand how pot affects the human mind before we can discuss the possibilities of mixing weed with Modafinil. Here are some of the most crucial facts you should know about marijuana, based on extensive study.

There are hundreds of naturally occurring compounds called “cannabinoids” in each cannabis plant. They attach to receptors on our cells and then have an influence on the rest of the body.

THC (delta-9-tetrahydrocannabinol) and CBD are the only two compounds you should be worried about for the time being (cannabidiol).

THC is psychoactive, which means it makes people feel “high” when they consume it. It’s also what makes stoners want more food and might cause paranoia and anxiety.

CBD is non-psychoactive and is best recognized for promoting relaxation and tranquillity. It’s often linked to a decrease in pain, anxiety, and any form of bodily or mental strain.

Isn’t it simple? That’s good, since there are two kinds of cannabis strains to be aware of [3]:

“Physically sedating indica strains are ideal for unwinding with a movie or as a nightcap before bed.”

Sativas are reported to provide energizing, elevating cerebral effects that work well with physical exercise, social gatherings, and creative endeavors.

Hybrids are regarded to be in the middle, providing a mix of indica and sativa effects.”

In general, Sativas have a greater THC concentration than CBD, and Indicas have a higher CBD concentration than THC.

This helps to understand why each strain has the characteristics listed above.

By now, it should be clear how Modafinil and marijuana may be combined to be beneficial.

As far as we can tell, the goal is to specify your desired result, choose the right strain, and utilize it at the right time.

For example, a Sativa strain might potentially raise your Modafinil dosage by increasing focus or creativity. An Indica strain, on the other hand, might counteract Modafinil’s sedative effects.

However, you must use the correct dosage. Too much CBD may wipe out Modafinil’s focus-enhancing benefits, while too much THC when taking Modafinil may overstimulate the mind and cause inattention.

The latter effect occurs because THC, like Modafinil, may enhance the release of dopamine, the feel-good hormone [4].

Of course, all of this is conjecture. What does research say about the effects of combining Modafinil with marijuana?

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What Does Science Say About Weed and Modafinil?

For decades, both medications have been extensively examined in isolation.

We already know a lot about Modafinil and marijuana as separate medications, which is why we have a good understanding of how they influence the body and mind.

But first, let’s go through the scientifically proved health advantages of each…

 

Modafinil Advantages

  • Modafinil Could Help With Addiction

Modafinil has recently been studied for its possible use as a therapy for drug addiction treatment.

Although the evidence is currently mixed, exploratory studies have been conducted to see whether Modafinil may assist those who are addicted to cocaine, meth, or other amphetamines.

The treatment result is determined by the substance under investigation [5]:

  • Lethargy and drowsiness are reduced.
  • It assists users in dealing with withdrawal symptoms.
  • Reduced cravings may help reduce the amount of relapses.

It is yet to be determined if Modafinil can be used to treat a marijuana addiction. We believe that either Modafinil eliminates the brain fog associated with pot use, or weed eliminates any increased motivation that results from taking Modafinil.

  • Modafinil enhances your ability to focus on tasks.

The study we’re going to show you is one of the few in which healthy participants were given a realistic dosage of Modafinil.

Sixty young adult men were given a placebo, 100 mg, or 200 mg of Modafinil before completing a variety of attention span and memory activities.

The following were the study’s main results [6]:

“Modafinil improved digit span, visual pattern recognition memory, spatial planning, and stop-signal response time considerably.”

On three tests: delayed matching to sample, a decision-making task, and spatial planning, these benefits were accompanied by a reduction in latency.

The medication made the subjects feel more alert, focused, and lively.”

This is by far the most typical observation of everyone who takes Modafinil, in our experience… particularly for the first time!

  • Fatigue And Tiredness Are Reduced By Modafinil

One of our favorite Modafinil Consequences is the ability to work for long periods of time without having to recharge or take a break.

There is no “n=1” impact here. Modafilnil’s potential to considerably relieve tiredness has been shown in several investigations [7]:

“Modafinil supplementation significantly reduces fatigue, especially during sleep deficit or hypersomnia.”

When we have an impossible deadline to achieve but are having trouble finding the energy to do it, we turn to good ol’ Modafinil.

 

Weed Advantages

  • Weed Could Help With Chronic Pain

While some of the alleged medicinal advantages of marijuana are debatable, pain alleviation has been a constant result.

The National Academies of Sciences, Engineering, and Medicine affirmed this after reviewing over 10,000 research [8]:

“Patients treated with cannabis or cannabinoids are more likely to achieve a clinically meaningful improvement in pain symptoms in adults with chronic pain.”

Weed seems to assist calm pain and simplify the healing process, whether you’re dealing with a little physical ailment or a sickness that causes a lot of discomfort.

  • Weed Could Boost Creativity

It’s one thing to be laser-focused, but we also need to relax and let thoughts float about freely in our heads from time to time.

This is why you’ll frequently hear about musicians and artists using marijuana to boost their creativity.

In a 2011 study, researchers discovered that acute cannabis usage boosted divergent thinking in both highly creative and uncreative people. Divergent thinking is the capacity to develop various thoughts on a given subject in a short amount of time.

Here’s one possible explanation for why this may occur [9]:

“…cannabis causes psychotomimetic effects, which may lead to the linking of apparently unrelated notions, a kind of divergent thinking thought to be essential to creative thinking.”  

Breaking out from typical thinking and connections may be possible as a result of a drug-induced altered state of mind, boosting the possibility of developing unique thoughts or associations.”

Of course, this should not be taken as gospel. Depending on the person who uses it, marijuana may have no impact on creativity at all — or possibly have a detrimental effect.

  • Weed Shows Potential as an Inflammation Treatment

While we don’t know whether being high will assist with chronic inflammation, we do know that cannabinoids found in marijuana may be beneficial [10]:

“…cannabinoids reduce inflammatory responses by downregulating cytokine and chemokine production and, in certain models, upregulating T-regulatory cells (Tregs), according to many studies.”

The authors of the cited research speculated that cannabis might be effective in treating rheumatoid arthritis, colitis, and a variety of other inflammatory illnesses.

 

 

Weed and Modafinil Benefits When Used Together!

If you go through the medical literature, you won’t find any research studying the usage of Modafinil and marijuana together – at least not in English!

We can only make an educated estimate as to how they will interact when combined.

We may also combine the information provided by our authors and readers who have tried Modafinil with marijuana.

  • Modafinil with marijuana may help you achieve a good balance of productivity and creativity.

As beneficial as Modafinil is as a cognitive enhancer, some users feel that it makes their thinking too rigid. Being laser-focused 24 hours a day, seven days a week implies you’re less likely to think outside the box or consider other options.

However, we don’t want to be so imaginative and open-minded that we lose sight of reality. So, what can we do to have the best of both worlds?

Taking Modafinil first thing in the morning and banging out as much technical work as feasible has worked for one contributor. He would then take a few hits of marijuana to fan the creative fire when he had a few hours open for freeform thinking.

  • Using Modafinil and Weed Together to Get Different Results?

While we haven’t tested it, some individuals claim that Modafinil and marijuana may be taken at the same time. However, we wouldn’t use marijuana until we’d had our fill of the 3-4 hours of peak productivity that Modafinil provides.

To increase dopamine release and boost work ethic, a tiny quantity of a Sativa strain might be used with Modafinil.

Similarly, a few tokes of an Indica strain may help alleviate some of Modafinil’s mild negative effects, such as anxiety and agitation.

After a hectic morning/afternoon utilizing Modafinil, we would let ourselves significantly more of the Indica strain at night to fully relax. This, in our opinion, would counteract Modafinil’s long-term effects and lead to a restful night’s sleep.

  • For Potential Parkinson’s Relief, Modafinil with Weed?

THC and modafinil were administered individually in an experimental investigation on marmosets with Parkinson’s disease to see whether they may be utilized as alternative therapies.

The discovery was fascinating [11]:

“9-THC increased activity and hand-eye coordination while also causing compound-related adverse effects.”

Modafinil helped with activity and parkinsonian symptoms, but not with hand-eye coordination.

Both chemicals show therapeutic potential and might be used to enhance current [Parkinson’s Disease] treatments.”

For what it’s worth, a different research found that 400 mg of Modafinil and 15 mg of THC may be taken safely together [12].

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The Most Significant Advantage?

Now, we’ve discussed a plethora of potential benefits when combining Weed and modafinil. Yet we didn’t cover what we think may be the  biggest benefit from mixing these two substances.

What is it?

Sleep.

In our experience, sleeplessness is one of Modafinil’s worst negative effects. Because of Modafinil’s extended half-life, many users find it difficult to go asleep at a regular hour after taking it throughout the day.

You may be able to fall asleep faster and sleep better if you use the correct sort of marijuana after a long day on Modafinil.

The major advantage of mixing cannabis and Modafinil, according to our staff members who have tested the two together, is enhanced sleep quality.

They usually take Modafinil first thing in the morning and then marijuana 1-2 hours before night.

Oh, and don’t worry if you don’t have any cannabis on hand or are legally forbidden from purchasing or using it.

CBD oil has also been shown to be helpful in the treatment of Modafinil-induced sleeplessness.

 

Consequences

So, what are the potential side effects of combining marijuana with Modafinil?

Again, none of these have been medically recorded, but here are some of the most prevalent observations among the courageous few who ventured to test this unusual combo…

  • Dry Mouth / Dehydration

One of the most common Consequences of Modafinil is dehydration, usually in the form of a dry mouth or dry eyes.

Marijuana, it turns out, produces the same adverse effect with the same frequency. Except that we know why it occurs.

Weed’s cannabinoids bind to receptors in your submandibular gland, which is responsible for saliva production. As a result, less saliva is generated, resulting in a dry mouth.

If you use Modafinil and marijuana at the same time, you should drink plenty of water and have a full water bottle with you at all times.

  • Anxiety Increase

Cannabis usage was shown to be positively linked with anxiety in a meta-analysis of 267 research including 110,000 individuals from ten countries [13]. The more you smoke, the more likely you are to get nervous.

While Modafinil does not usually cause anxiety, it has been seen in certain individuals. However, these people were already anxious before they started using Modafinil.

We believe it is crucial for worried persons to avoid any strain with a high THC concentration while consuming cannabis and Modafinil together. If anything, an Indica strain heavy in CBD may be able to bring them down to a level of concentration that they can maintain for many hours.

  • Long-Term Negative Effects

Modafinil and marijuana, on their own, may have long-lasting effects. Modafinil has a half-life of 12-15 hours, but THC’s half-life may range from a day to a week, depending on how often you use it.

Keep in mind that the former is a CNS stimulant, while the latter is generally classified as a depression. Combining stimulants and depressants may be dangerous depending on your biology [14]:

“One of the risks of mixing the two is that the stimulant may hide the depressant’s effects” (most commonly alcohol).

This may lead to a false feeling of sobriety and alertness, which can lead to increased and unsafe levels of [depressant] intake, as well as a false sense of security, which can lead to risky behaviors like driving or operating heavy equipment.”

Smart drug users who genuinely want to be safe should take their Modafinil and marijuana on different days.

 

 

Is the Risk Worth It? | Conclusion

Modafinil with marijuana, in our experience, may be one of those pairings that either works incredibly well, does nothing for you, or causes undesired side effects.

Overall, it’s a combo that seasoned smart drug users should think about.

To discover the perfect mix, our authors had to experiment with a variety of factors…

  • When to use marijuana and which strain to use.
  • When to take Modafinil and what dosage to take.

There are four main aspects that might affect the final result, and it takes a lot of tinkering to figure out what works best for each person.

However, if it proves to be helpful, it may be a marriage made in heaven.

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References

  1. RD Teodorini, N Rycroft, and JH Smith-Spark. An online study assessing perceived hazards and advantages of modafinil usage off-label. doi:10.1371/journal.pone.0227818. PLoS One. 2020;15(2):e0227818.
  2. Medications for Narcolepsy Modafinil Is The First “Safe” Smart Drug In The World. The date is April 3, 2020. Inverse.com
  3. What’s the difference between indica and sativa cannabis? The date is April 4, 2020. Leafly.ca
  4. MA Bloomfield, AH Ashok, ND Volkow, and OD Howes. The dopamine system’s effects on 9-tetrahydrocannabinol. 369–377 in Nature 539(7629), doi:10.1038/nature20153.
  5. Is Modafinil Effective in the Treatment of Addiction? Oxfordtreatment.com (accessed April 5, 2020).
  6. DC Turner, TW Robbins, L Clark, AR Aron, J Dowson, et al. Modafinil’s cognitive boosting effects on healthy individuals. Pharmacology of the mind (Berl). 2003 Jan;165(3):260-9.
  7. Modafinil. The date is April 4, 2020. Examine.com
  8. The National Academies of Sciences, Engineering, and Medicine published this report in 2017. The Current State of Evidence and Research Recommendations for Cannabis and Cannabinoids’ Health Effects The National Academies Press, Washington, DC. https://doi.org/10.17226/24625.

  9. Cannabis and the Arts The date is April 5, 2020. Psychologytoday.com
  10. Cannabinoids as new anti-inflammatory medications, Nagarkatti P, Pandey R, Rieder SA, Hegde VL, Nagarkatti M. Future Medical Chemistry, 1(7), 1333–1349. doi:10.4155/fmc.09.93.
  11. SAM van Vliet, RAP Vanwersch, MJ Jongsma, B Olivier, IHCHM Philippens In a marmoset Parkinson model, 9-THC and modafinil have therapeutic benefits. 2008;18(5):383-389 in Eur Neuropsychopharm.

     

  12. DE Sugarman, J Poling, M Sofuoglu. In humans, the safety of modafinil combined with oral 9-tetrahydrocannabinol. 98(1):94–100 in Pharmacol Biochem Behav. doi:10.1016/j.pbb.2010.12.013.
  13. A meta-analysis of 31 studies found a favorable connection between anxiety disorders and cannabis use or cannabis use disorders in the general population. doi:10.1186/1471-244X-14-136. BMC Psychiatry. 2014;14:136.
  14. As a cognitive enhancer, modafinil is used. The date is April 6, 2020. Digitalwindow.vassar.edu

 

 

Modafinil is a drug that has been used for a long time in the military. It has also been used by students who want to study more and get better grades. However, it is not recommended to use while using marijuana. Reference: modafinil makes me want to drink.

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About P. Tardner

Paul Tardner is the Lead Author at IJEST.org. Paul is a former academic and research scientists. He now dedicates his time to his own research into natural biohacking, with a particular focus on cognitive enhancement.

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