Piracetam as well as Phenylpiracetam are two popular substances that improve cognition, memory mental state, mood. Piracetam and Phenylpiracetam are two of the most widely used nootropics today, with people alternatively claiming that one of these racetams is far superior to the other.
Prior to the advent of nootropics as a mainstream intelligent drug relied on the usual stimulants like caffeine. It is true that it has stimulant effects, but not the possibility of enhancing cognition, aside from showing only short-term effects. That’s where nootropics like racetams come in.
Piracetam as well as Phenylpiracetam are two of the most popular trends in the nootropics world. They aren’t considered smart drugs to treat any medical conditions, but they are widely used to enhance cognitive performance. These two compounds are generally considered two of the best racetams you can use.
In this article we will learn more about these popular nootropic smart drugs and the benefits they provide. We will directly compare Piracetam and Phenylpiracetam, and at the end we’ll tell you which is better.
Piracetam
Discovered in 1964, Piracetam (4-phenylpiracetam)is the original member of the racetam family of synthetic nootropics or “”cognitive-enhancing”” compounds.
The theory is that it’s much less powerful than other compounds belonging to the “”racetam”” family.
Its advantages include mild but solid cognitive enhancement, which is extremely effective in those with learning disabilities because it reduces depression and anxiety, as well as maintaining Mitochondria.
Mitochondria provide energy to cells. If mitochondria are damaged they can begin producing free radicals that cause destruction and oxidation to the brain.
Piracetam assists damaged mitochondria to recognize the cell’s signals to self-destruct and generate new mitochondria that are not broken.
This original racetam has the best track record for safety that any other racetam has. People will often compare Noopept and Piracetam, and while the former has a similar safety profile to the latter, Noopept is not actually a racetam!
Phenylpiracetam
The year 1983 was the first time Phenylpiracetam also known as phenyl piracetam was developed to be an even more potent Pramiracetam. It’s 30x more potent than Piracetam. Phenylpiracetam enhances the tolerance to cold and pain. It improves mood and reduces anxiety in social situations, as it functions as an anti-convulsant and anti-depressant.
A study suggests using Phenylpiracetam when you’re planning to travel to Siberia or after you’ve tried the other racetams and you’re looking to pull out the top guns. The phenyl group was specifically designed to treat Soviet Cosmonauts in the 1980s to ease the stress of long-term conditions during space travel.
Despite the lack of studies, those living in Russia have access to this nooropic and it is readily available as a legally prescribed medicine.
Research has shown that Piracetam-like drugs like Aniracetam as well as phenyl group Phenylpiracetam can be efficient to stop cognitive loss and improving memory.
This means they could enhance brain function and serve as an alternative treatments for those suffering from stroke or dementia.
What are Racetams?
Racetam is a class of chemical compounds that are part of the family of nootropics. It is comprised of similar chemicals with identical properties, but differ from each others based on the formula for structural structure.
The only things that are shared in their structure are the two pyrrolidone nuclei composed of oxygen, nitrogen, and hydrogen.
Piracetam was first discovered in the mid- to late 1960s. Since then, over 20 derivatives were synthesized, including phenylpiracetam.
Certain of these compounds are not thoroughly studied, and they differ in their potency and mechanism of action. Below are some common examples for these compounds.
Aniracetam (N-anisoyl-2-pyrrolidinone) is a pyrrolidinone-type cognition enhancer similar to Piracetam and developed around the 1970s. It’s 2-5x more powerful than Piracetam.
Aniracetam is anti-anxiety, calms, and relaxation effects. It improves the ability to think and communicate. fluency, and can also promote dreams that are lucid.
Aniracetam can also boost confidence in social situations , and increases creativity.
Oxiracetam(2 Oxo) is an organic compound as well as one of the organonitrogen compounds. It is derived from an alpha-amino acids. This is an nootropic medication belonging to the racetam family. It is an extremely mild stimulant.
Oxiracetam was first discovered in 1977. It is a stimulant and has a speedy effect, increases focus and improves the ability to think logically.
A study has confirmed that Oxiracetam is believed to increase excitation neurotransmitters, and also enhance memory creation.
Piracetam vs Phenylpiracetam
According to research that found that people frequently use Phenylpiracetam to achieve the same results when they take Piracetam as well as Pramiracetam. These nootropics can help with laser-sharp focus, concentration and enhanced long-term memory.
It is recommended to take any of the racetams when you’re working on a large project that requires you to put your feet down to finish it.
However, due to the different laboratory orientations, Piracetam and Phenylpiracetam have diverse dose, potency metabolism, absorption, half-life, and elimination rates.
Mechanisms of Action of Racetams
Piracetam mechanism affects the neuronal and vascular processes. It can affect cognitive function, but without being a sedative or stimulant.
While it is an allosteric positive modulator that is a positive allosteric modulator AMPA receptor, the mechanism of action is not very strong and could not be the primary driver of the clinical manifestations of AMPA.
The substance is believed to interact with Ion channels, also known as Ion carriers, resulting in an increase in neuronal excitability.
It doesn’t affect GABA metabolism or GABA receptors since it doesn’t traverse the blood-brain barrier.
According to studies, Piracetam and choline taken together are also believed to improve cognition and memory in animals. This is due to the fact that acetylcholine regulates cognitive functions. It works in similarly when combined together with Aniracetam, Pramiracetam, or Oxiracetam.
On the other hand, Phenylpiracetam’s structure Phenylpiracetammakes it capable of navigating across the blood brain barrier.
Because of this, it only requires just a tiny quantity of Phenylpiracetam to feel the same effects as those experienced by a normal Piracetam dose.
One study has shown that Phenylpiracetam is able to reverse the depressant effects of diazepam, a benzodiazepine benzodiaze results in a highly operant behaviour. It also reduces post-rotational nystagmus, which prevents retrograde amnesia and also has anticonvulsant properties.
What are Piracetam and Phenylpiracetam Used for and How Do They Work?
Piracetam is is most often prescribed for seizures, breath-holding disorders (epilepsy) and the dizziness (vertigo).
Research has also shown that it is used to treat a learning disorder characterized by reading difficulties (dyslexia) as well as a movement disorder that is often caused by antipsychotic medications (tardive dyskinesia).
Health information clearly emphasized the function of the neurotransmitter acetylcholine through muscarinic cholinergic (Ach) receptors that are involved in memory processing improved.
Phenylpiracetam (Phenotropil) is a drug that matches chemicals that may contain choline and helps people counteract depression, traumatic injury, and encephalopathy.
In short, studies on health can be confidently conclusive that this supplement has superior neuroprotective qualities.
Phenylpiracetam (Phenotropil) can reduce amnesia induced by drugs. It has anticonvulsant properties and the general stimulation of the nervous system since the compound reduces anxiety and fear.
While Phenylpiracetam can be a stimulant, people need not worry as it won’t cause anxiety, as is the case of amphetamines or caffeine.
Clinically, it’s utilized to treat epilepsy, ADHD stroke, epilepsy, or brain injuries It has also been studied to treat Parkinson’s disease.
In addition, Phenylpiracetam increases tolerance and the sensitivity for extreme conditions. These are the reason why Phenylpiracetam was originally created to aid Russian Cosmonauts.
Cosmonaut-pilot Aleksandr Serebrov described being issued and taking Phenylpiracetam. It’s part of the Soyuz spacecraft’s standard medical kit for his 197 days working on the spacecraft Mir Space Station. He said, “”the drug acts as an equalizer for the entire organism, and ‘combs completely,’removing the irritability and impulsiveness that are common during the stress of space travel.
Benefits and Side Effects of Piracetam and Phenylpiracetam
Researchers aren’t completely certain of the way that Piracetam works. However, research studies have linked the drug to numerous benefits. It improves brain function, decreases dyslexia-related symptoms, and also protects against myoclonic seizures.
It also helps reduce the symptoms of Alzheimer’s disease. It also reduces inflammation as well as provide relief from pain.
The most common side effects of Piracetam are weight gain, diarrhea, insomnia, drowsiness anxiety, depression, nervousness hyperactivity, muscle spasms, and the rash.
But, Phenylpiracetam describes the following effects: enhancement of regional blood flow within the brain’s ischemic areas and decreasing anxiety and depression.
Phenylpiracetam is a psycho-activator by increasing the threshold of pain and improving the quality of sleep in addition to being an anticonvulsant. It also has an anorexic impact with prolonged usage.
In certain instances patients may suffer from side effects, such as difficulties falling asleep, headaches and nausea.
Research has shown that long-term usage one of the dangers of Phenylpiracetam and negative effects could result in dependency if you increase dosages and use high doses to increase tolerance faster than any other Racetams.
It is recommended to seek advice from a doctor prior to taking Piracetam or Phenylpircetam. We are not doctors and this is not medical advice.
What Do They Feel Like?
One of the main reasons that people take racetams like Piracetam and Phenylpiracetam is because of the feeling they produce. It is wrong to say that either of these racetams produce any kind of high, but taking racetams does have a distinctive feel to it.
Both piracetam and phenylpiracetam produce similar feelings or “highs”. On the positive side, these nootropics quickly sharpen focus, increase mental energy, and overall quicker cognitively. They can put people in a tunnel vision-like state of focus and drive.
On the negative side, both piracetam and phenylpiracetam can make you feel terrible. Side effects include psychomotor agitation, dysphoria, tiredness, dizziness, memory loss, headache, and diarrhea.
Dosage and How to Take
Piracetam is typically sold as a powder however, it can also be found in pre-made (pre-packaged and dosed) tablets or capsules.
In the case of a “”typical”” dose for adults of cognitive enhancement, the dosage is between 1,200mg and 4,800mg daily, usually divided into two or three different doses spread all day.
The typical Phenylpiracetam dosage is between 200mg-300mg daily. For instance stroke patients have a maximum dosage of 400 mg per day. For those suffering from brain issues, a dose of 200mg daily is sufficient to cause changes on the brain’s surface.
The oral administration can be done every week, either once or twice. As a first-time user dosage, 50mg should be sufficient. For experienced users, you can may go as high as 600 mg.
FDA Status and Safety
The year 2003 was the first time Piracetam was not approved for in the new Dietary Ingredient (NDI) application which is a procedure that is used to assess the safety of novel ingredients in the marketplace.
It didn’t meet the requirements of a supplement. In the warning in the warning, the FDA reiterates that all racetams are unapproved substances since the therapeutic information isn’t readily available. This is the same for the subsequent racetams. Therefore, they aren’t typically recognized as safe and efficient for the intended uses by experts.
However, racetams like Piracetam and Phenylpiracetam continue to be available online. It is worth noting here that Phenylpiracetam is sometimes mistakenly referred to as phenylracetam. This makes perfect sense, since it is the only racetam with a phenyl group attatched widely used today. But when you see phenylracetam, it’s actually phenylpiracetam.
Conclusion: Which is better Piracetam or Phenylpiracetam?
Phenylpiracetam is more potent than piracetam, but that does not mean that it is better for everyone. Piracetam and phenylpiracetam have different benefits. It is important that you look at the individual benefits and drawbacks of both racetams and choose the one that works for you.
Racetams are the pioneers of smart drugs and nootropics. They can be effective in enhancing reasoning, comprehension learning, memory, and comprehension.
While some people are concerned about adverse effects, it’s very simple to follow the instructions and avoid these unpleasant signs.
Nootropic users report headaches frequently however stacking Racetam with an choline supplement can solve the problem.
To ensure you are on the safe side, make sure you make use of the Racetam nootropic with a scientific backing, which includes existent human clinical research.
Always research thoroughly and consult your doctor or a medical professional prior to beginning any new medication.
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Paul Tardner is the Head Writer at IJEST.org. Paul is a former academic and research scientist. He now dedicates his time to his own research into nootropics, with a particular focus on cognitive enhancement in old age. You can learn more about Paul from his profile page.